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Daily Heart Rate Variability Indices in Subjects with and Without Metabolic Syndrome Before and After the Elimination of the Influence of Day-time Physical Activity

Background and Objectives: The available research shows conflicting data on the heart rate variability (HRV) in metabolic syndrome (MetS) subjects. The discrepancy suggests a methodical shortcoming: due to the influence of physical activity, the standard measuring of HRV at rest is not comparable wi...

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Autores principales: Slušnienė, Anžela, Laucevičius, Aleksandras, Navickas, Petras, Ryliškytė, Ligita, Stankus, Vytautas, Stankus, Albinas, Navickas, Rokas, Laucevičienė, Ieva, Kasiulevičius, Vytautas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843357/
https://www.ncbi.nlm.nih.gov/pubmed/31627461
http://dx.doi.org/10.3390/medicina55100700
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author Slušnienė, Anžela
Laucevičius, Aleksandras
Navickas, Petras
Ryliškytė, Ligita
Stankus, Vytautas
Stankus, Albinas
Navickas, Rokas
Laucevičienė, Ieva
Kasiulevičius, Vytautas
author_facet Slušnienė, Anžela
Laucevičius, Aleksandras
Navickas, Petras
Ryliškytė, Ligita
Stankus, Vytautas
Stankus, Albinas
Navickas, Rokas
Laucevičienė, Ieva
Kasiulevičius, Vytautas
author_sort Slušnienė, Anžela
collection PubMed
description Background and Objectives: The available research shows conflicting data on the heart rate variability (HRV) in metabolic syndrome (MetS) subjects. The discrepancy suggests a methodical shortcoming: due to the influence of physical activity, the standard measuring of HRV at rest is not comparable with HRV assessment based on 24 h Holter monitoring, which is preferred because of its comprehensiveness. To obtain a more reliable measure and to clarify to what extent HRV is altered in MetS, we assessed a 24 h HRV before and after the elimination of the influence of physical activity. Materials and Methods: We investigated 69 metabolic syndrome (MetS) and 37 control subjects, aged 50–55. In all subjects, 24 h monitoring of electrocardiogram, blood pressure, and actigraphy profiles were conducted. To eliminate the influence of day-time physical activity on RR intervals (RRI), a linear polynomial autoregressive model with exogenous terms (ARX) was used. Standard spectral RRI analysis was performed. Results: Subjects with MetS had blunted HRV; the diurnal SDNN index was reliably lower in the MetS group than in control subjects. The elimination of the influence of physical activity did not reveal a significant HRV change in long-term indices (SDNN, SDANN, and SD2), whilst adjacent RRI values (RMSSD, pNN50, and SD1) and SDNN index significantly increased (p < 0.001). An increase in the latter indices highlighted the HRV difference between the MetS and control groups; a significant (p < 0.001) decrease of all short-term HRV variables was found in the MetS group (p < 0.01), and low-frequency spectral components were less pronounced in the MetS group. Conclusion: The application of a polynomial autoregressive model in 24 h HRV assessment allowed for the exclusion of the influence of physical activity and revealed that MetS is associated with blunted HRV, which reflects mitigated parasympathetic tone.
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spelling pubmed-68433572019-11-25 Daily Heart Rate Variability Indices in Subjects with and Without Metabolic Syndrome Before and After the Elimination of the Influence of Day-time Physical Activity Slušnienė, Anžela Laucevičius, Aleksandras Navickas, Petras Ryliškytė, Ligita Stankus, Vytautas Stankus, Albinas Navickas, Rokas Laucevičienė, Ieva Kasiulevičius, Vytautas Medicina (Kaunas) Article Background and Objectives: The available research shows conflicting data on the heart rate variability (HRV) in metabolic syndrome (MetS) subjects. The discrepancy suggests a methodical shortcoming: due to the influence of physical activity, the standard measuring of HRV at rest is not comparable with HRV assessment based on 24 h Holter monitoring, which is preferred because of its comprehensiveness. To obtain a more reliable measure and to clarify to what extent HRV is altered in MetS, we assessed a 24 h HRV before and after the elimination of the influence of physical activity. Materials and Methods: We investigated 69 metabolic syndrome (MetS) and 37 control subjects, aged 50–55. In all subjects, 24 h monitoring of electrocardiogram, blood pressure, and actigraphy profiles were conducted. To eliminate the influence of day-time physical activity on RR intervals (RRI), a linear polynomial autoregressive model with exogenous terms (ARX) was used. Standard spectral RRI analysis was performed. Results: Subjects with MetS had blunted HRV; the diurnal SDNN index was reliably lower in the MetS group than in control subjects. The elimination of the influence of physical activity did not reveal a significant HRV change in long-term indices (SDNN, SDANN, and SD2), whilst adjacent RRI values (RMSSD, pNN50, and SD1) and SDNN index significantly increased (p < 0.001). An increase in the latter indices highlighted the HRV difference between the MetS and control groups; a significant (p < 0.001) decrease of all short-term HRV variables was found in the MetS group (p < 0.01), and low-frequency spectral components were less pronounced in the MetS group. Conclusion: The application of a polynomial autoregressive model in 24 h HRV assessment allowed for the exclusion of the influence of physical activity and revealed that MetS is associated with blunted HRV, which reflects mitigated parasympathetic tone. MDPI 2019-10-17 /pmc/articles/PMC6843357/ /pubmed/31627461 http://dx.doi.org/10.3390/medicina55100700 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Slušnienė, Anžela
Laucevičius, Aleksandras
Navickas, Petras
Ryliškytė, Ligita
Stankus, Vytautas
Stankus, Albinas
Navickas, Rokas
Laucevičienė, Ieva
Kasiulevičius, Vytautas
Daily Heart Rate Variability Indices in Subjects with and Without Metabolic Syndrome Before and After the Elimination of the Influence of Day-time Physical Activity
title Daily Heart Rate Variability Indices in Subjects with and Without Metabolic Syndrome Before and After the Elimination of the Influence of Day-time Physical Activity
title_full Daily Heart Rate Variability Indices in Subjects with and Without Metabolic Syndrome Before and After the Elimination of the Influence of Day-time Physical Activity
title_fullStr Daily Heart Rate Variability Indices in Subjects with and Without Metabolic Syndrome Before and After the Elimination of the Influence of Day-time Physical Activity
title_full_unstemmed Daily Heart Rate Variability Indices in Subjects with and Without Metabolic Syndrome Before and After the Elimination of the Influence of Day-time Physical Activity
title_short Daily Heart Rate Variability Indices in Subjects with and Without Metabolic Syndrome Before and After the Elimination of the Influence of Day-time Physical Activity
title_sort daily heart rate variability indices in subjects with and without metabolic syndrome before and after the elimination of the influence of day-time physical activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843357/
https://www.ncbi.nlm.nih.gov/pubmed/31627461
http://dx.doi.org/10.3390/medicina55100700
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