Cargando…

In Vitro Evaluation of Neutral Aryloximes as Reactivators for Electrophorus eel Acetylcholinesterase Inhibited by Paraoxon

Casualties caused by organophosphorus pesticides are a burden for health systems in developing and poor countries. Such compounds are potent acetylcholinesterase irreversible inhibitors, and share the toxic profile with nerve agents. Pyridinium oximes are the only clinically available antidotes agai...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kitagawa, Daniel A. S., Cavalcante, Samir F. de A., de Paula, Reuel L., Rodrigues, Rafael B., Bernardo, Leandro B., da Silva, Munique C. J., da Silva, Thiago N., dos Santos, Wellington V., Granjeiro, José M., de Almeida, Joyce S. F. D., Barcellos, Marcos C., de A. Correa, Ana Beatriz, França, Tanos C. C., Kuča, Kamil, Simas, Alessandro B. C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843506/ https://www.ncbi.nlm.nih.gov/pubmed/31597234 http://dx.doi.org/10.3390/biom9100583

Ejemplares similares

Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon
por: de Paula, Reuel L., et al.
Publicado: (2018)

Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention
por: Cavalcante, Samir F. de A., et al.
Publicado: (2020)

Phenolic Lipids Affect the Activity and Conformation of Acetylcholinesterase from Electrophorus electricus (Electric eel)
por: Stasiuk, Maria, et al.
Publicado: (2014)

Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon
por: Kuca, Kamil, et al.
Publicado: (2018)

The Untold Story of the Caudal Skeleton in the Electric Eel (Ostariophysi: Gymnotiformes: Electrophorus)
por: de Santana, Carlos David, et al.
Publicado: (2013)

Novel Bisquaternary Oximes—Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon
por: Kuca, Kamil, et al.
Publicado: (2009)

Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators
por: Kitagawa, Daniel A. S., et al.
Publicado: (2021)

Spontaneous peripheral neuritis in two electric eels (Electrophorus electricus)
por: RAHMAN, Nahid, et al.
Publicado: (2019)

THE ASSOCIATION OF ACETYLCHOLINESTERASE AND MEMBRANE IN SUBCELLULAR FRACTIONS OF THE ELECTRIC TISSUE OF ELECTROPHORUS
por: Karlin, Arthur
Publicado: (1965)

Combined Pre- and Posttreatment of Paraoxon Exposure
por: Lorke, Dietrich E, et al.
Publicado: (2020)

Electrophorus acetylcholinesterase. Biochemical and electron microscope characterization of low ionic strength aggregates
Publicado: (1978)

Evaluation of a Brain Acetylcholinesterase Extraction Method and Kinetic Constants after Methyl-Paraoxon Inhibition in Three Brazilian Fish Species
por: Freitas, A. P., et al.
Publicado: (2016)

Unique patterns of transcript and miRNA expression in the South American strong voltage electric eel (Electrophorus electricus)
por: Traeger, Lindsay L, et al.
Publicado: (2015)

Study on Spontaneous Reactivation and Aging of Acetylcholinesterase Inhibited by Paraoxon and Malaoxon in Ten Species
por: Gao, Mingwei, et al.
Publicado: (2023)

Novichoks: The Dangerous Fourth Generation of Chemical Weapons
por: Franca, Tanos C. C., et al.
Publicado: (2019)

A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase
por: Kuca, Kamil, et al.
Publicado: (2018)

Reactivation of VX-Inhibited Human Acetylcholinesterase by Deprotonated Pralidoxime. A Complementary Quantum Mechanical Study
por: da Silva, Jorge Alberto Valle, et al.
Publicado: (2020)

FINE STRUCTURAL LOCALIZATION OF ACETYLCHOLINESTERASE IN ELECTROPLAQUE OF THE ELECTRIC EEL
por: Bloom, Floyd E., et al.
Publicado: (1966)

Voltage-Gated Na(+) Channel Isoforms and Their mRNA Expression Levels and Protein Abundance in Three Electric Organs and the Skeletal Muscle of the Electric Eel Electrophorus electricus
por: Ching, Biyun, et al.
Publicado: (2016)

Molecular Modeling Studies on the Interactions of Aflatoxin B1 and Its Metabolites with Human Acetylcholinesterase. Part II: Interactions with the Catalytic Anionic Site (CAS)
por: de Almeida, Joyce S. F. D., et al.
Publicado: (2018)

Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach
por: da Silva, Jorge Alberto Valle, et al.
Publicado: (2019)

Fluorescent Silicate Materials for the Detection of Paraoxon
por: Johnson, Brandy J., et al.
Publicado: (2010)

Enhancing Paraoxon Binding to Organophosphorus Hydrolase Active Site
por: El Khoury, Léa, et al.
Publicado: (2021)

Safety and Efficacy of New Oximes to Reverse Low Dose Diethyl-Paraoxon-Induced Ventilatory Effects in Rats
por: Kayouka, Maya, et al.
Publicado: (2020)

ELECTRIC POTENTIAL AND ACTIVITY OF CHOLINE ESTERASE IN THE ELECTRIC ORGAN OF ELECTROPHORUS ELECTRICUS (LINNAEUS)
por: Nachmansohn, D., et al.
Publicado: (1941)

Hierarchical Virtual Screening of Potential Insectides Inhibitors of Acetylcholinesterase and Juvenile Hormone from Temephos
por: V. da Costa, Glauber, et al.
Publicado: (2019)

Conductance Properties of Artificial Lipidic Membranes Containing a Proteolipid from Electrophorus : Response to cholinergic agents
por: Parisi, Mario, et al.
Publicado: (1972)

Binding of antibodies to acetylcholine receptors in Electrophorus and Torpedo electroplax membranes
Publicado: (1978)

Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes
por: Magnin, Geraldine, et al.
Publicado: (2019)

Acetylcholinesterase inhibition in electric eel and human donor blood: an in vitro approach to investigate interspecies differences and human variability in toxicodynamics
por: Kasteel, Emma E. J., et al.
Publicado: (2020)

Patch recordings from the electrocytes of electrophorus. Na channel gating currents
Publicado: (1991)

Conductance increases produced by bath application of cholinergic agonists to Electrophorus electroplaques
Publicado: (1975)

The effects of external Ca++ and Mg++ on the voltage sensitivity of desensitization in Electrophorus electroplaques
Publicado: (1980)

Rates and equilibria for a photoisomerizable antagonist at the acetylcholine receptor of Electrophorus electroplaques
Publicado: (1985)

Nephrotoxic Effects of Paraoxon in Three Rat Models of Acute Intoxication
por: Sobolev, Vladislav E., et al.
Publicado: (2021)

A Butyrylcholinesterase Camera Biosensor Tested for Carbofuran and Paraoxon Assay
por: Pohanka, Miroslav, et al.
Publicado: (2022)

Na+/K+-ATPase α-subunit (nkaα) Isoforms and Their mRNA Expression Levels, Overall Nkaα Protein Abundance, and Kinetic Properties of Nka in the Skeletal Muscle and Three Electric Organs of the Electric Eel, Electrophorus electricus
por: Ching, Biyun, et al.
Publicado: (2015)

A FRET Approach to Detect Paraoxon among Organophosphate Pesticides Using a Fluorescent Biosensor
por: Rodrigues, Andreia C. M., et al.
Publicado: (2022)

Synthesis and Inhibition Evaluation of New Benzyltetrahydroprotoberberine Alkaloids Designed as Acetylcholinesterase Inhibitors
por: de Lima, Bruna R., et al.
Publicado: (2019)

Analysis of Spike Electrogenesis and Depolarizing K Inactivation in Electroplaques of Electrophorus electricus, L
por: Nakamura, Yutaka, et al.
Publicado: (1965)

Cannot write session to /tmp/vufind_sessions/sess_9u5rn76k3jo2d0bql0ndjf0m1b