Cargando…
Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease—A Cross Sectional Study
Background and Objectives: The aim of the study was to determine the association between presences of fatty pancreas (FP) with the features of metabolic syndrome (MeS) in patients with non–alcoholic fatty liver disease (NAFLD) and to establish a new noninvasive scoring system for the prediction of F...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843527/ https://www.ncbi.nlm.nih.gov/pubmed/31627351 http://dx.doi.org/10.3390/medicina55100697 |
_version_ | 1783468236663160832 |
---|---|
author | Milovanovic, Tamara Dragasevic, Sanja Stojkovic Lalosevic, Milica Zgradic, Sanja Milicic, Biljana Dumic, Igor Kmezic, Stefan Saponjski, Dusan Antic, Andrija Markovic, Velimir Popovic, Dragan |
author_facet | Milovanovic, Tamara Dragasevic, Sanja Stojkovic Lalosevic, Milica Zgradic, Sanja Milicic, Biljana Dumic, Igor Kmezic, Stefan Saponjski, Dusan Antic, Andrija Markovic, Velimir Popovic, Dragan |
author_sort | Milovanovic, Tamara |
collection | PubMed |
description | Background and Objectives: The aim of the study was to determine the association between presences of fatty pancreas (FP) with the features of metabolic syndrome (MeS) in patients with non–alcoholic fatty liver disease (NAFLD) and to establish a new noninvasive scoring system for the prediction of FP in patients with NAFLD. Material and Methods: 143 patients with NAFLD were classified according to FP severity grade into the two groups and evaluated for diagnostic criteria of MeS. All patients underwent sonographic examination with adiposity measurements and the liver biopsy. Liver fibrosis was evaluated semi-quantitatively according to the METAVIR scoring system and using non-invasive markers of hepatic fibrosis. Results: Waist circumference (WC) was predictive for increased risk of FP in NAFLD patients. Elevated fasting plasma glucose, total cholesterol, serum amylase and lipase levels were associated with presence of severe FP (p value = 0.052, p value = 0.007, p value = 0.014; p value = 0.024, respectively). Presence of increased amounts of mesenteric fat was associated with severe FP (p value = 0.013). The results of this study demonstrated highly significant association between NAFLD and presence of FP. The model for predicting the presence of FP was designed with probability value above 6.5. Conclusion: Pancreatic fat accumulation leads to worsening of pancreatic function which in turns exacerbates severity of metabolic syndrome associated with both, NAFLD and NAFPD. |
format | Online Article Text |
id | pubmed-6843527 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68435272019-11-25 Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease—A Cross Sectional Study Milovanovic, Tamara Dragasevic, Sanja Stojkovic Lalosevic, Milica Zgradic, Sanja Milicic, Biljana Dumic, Igor Kmezic, Stefan Saponjski, Dusan Antic, Andrija Markovic, Velimir Popovic, Dragan Medicina (Kaunas) Article Background and Objectives: The aim of the study was to determine the association between presences of fatty pancreas (FP) with the features of metabolic syndrome (MeS) in patients with non–alcoholic fatty liver disease (NAFLD) and to establish a new noninvasive scoring system for the prediction of FP in patients with NAFLD. Material and Methods: 143 patients with NAFLD were classified according to FP severity grade into the two groups and evaluated for diagnostic criteria of MeS. All patients underwent sonographic examination with adiposity measurements and the liver biopsy. Liver fibrosis was evaluated semi-quantitatively according to the METAVIR scoring system and using non-invasive markers of hepatic fibrosis. Results: Waist circumference (WC) was predictive for increased risk of FP in NAFLD patients. Elevated fasting plasma glucose, total cholesterol, serum amylase and lipase levels were associated with presence of severe FP (p value = 0.052, p value = 0.007, p value = 0.014; p value = 0.024, respectively). Presence of increased amounts of mesenteric fat was associated with severe FP (p value = 0.013). The results of this study demonstrated highly significant association between NAFLD and presence of FP. The model for predicting the presence of FP was designed with probability value above 6.5. Conclusion: Pancreatic fat accumulation leads to worsening of pancreatic function which in turns exacerbates severity of metabolic syndrome associated with both, NAFLD and NAFPD. MDPI 2019-10-17 /pmc/articles/PMC6843527/ /pubmed/31627351 http://dx.doi.org/10.3390/medicina55100697 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Milovanovic, Tamara Dragasevic, Sanja Stojkovic Lalosevic, Milica Zgradic, Sanja Milicic, Biljana Dumic, Igor Kmezic, Stefan Saponjski, Dusan Antic, Andrija Markovic, Velimir Popovic, Dragan Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease—A Cross Sectional Study |
title | Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease—A Cross Sectional Study |
title_full | Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease—A Cross Sectional Study |
title_fullStr | Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease—A Cross Sectional Study |
title_full_unstemmed | Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease—A Cross Sectional Study |
title_short | Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease—A Cross Sectional Study |
title_sort | ultrasonographic evaluation of fatty pancreas in serbian patients with non alcoholic fatty liver disease—a cross sectional study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843527/ https://www.ncbi.nlm.nih.gov/pubmed/31627351 http://dx.doi.org/10.3390/medicina55100697 |
work_keys_str_mv | AT milovanovictamara ultrasonographicevaluationoffattypancreasinserbianpatientswithnonalcoholicfattyliverdiseaseacrosssectionalstudy AT dragasevicsanja ultrasonographicevaluationoffattypancreasinserbianpatientswithnonalcoholicfattyliverdiseaseacrosssectionalstudy AT stojkoviclalosevicmilica ultrasonographicevaluationoffattypancreasinserbianpatientswithnonalcoholicfattyliverdiseaseacrosssectionalstudy AT zgradicsanja ultrasonographicevaluationoffattypancreasinserbianpatientswithnonalcoholicfattyliverdiseaseacrosssectionalstudy AT milicicbiljana ultrasonographicevaluationoffattypancreasinserbianpatientswithnonalcoholicfattyliverdiseaseacrosssectionalstudy AT dumicigor ultrasonographicevaluationoffattypancreasinserbianpatientswithnonalcoholicfattyliverdiseaseacrosssectionalstudy AT kmezicstefan ultrasonographicevaluationoffattypancreasinserbianpatientswithnonalcoholicfattyliverdiseaseacrosssectionalstudy AT saponjskidusan ultrasonographicevaluationoffattypancreasinserbianpatientswithnonalcoholicfattyliverdiseaseacrosssectionalstudy AT anticandrija ultrasonographicevaluationoffattypancreasinserbianpatientswithnonalcoholicfattyliverdiseaseacrosssectionalstudy AT markovicvelimir ultrasonographicevaluationoffattypancreasinserbianpatientswithnonalcoholicfattyliverdiseaseacrosssectionalstudy AT popovicdragan ultrasonographicevaluationoffattypancreasinserbianpatientswithnonalcoholicfattyliverdiseaseacrosssectionalstudy |