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Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease—A Cross Sectional Study

Background and Objectives: The aim of the study was to determine the association between presences of fatty pancreas (FP) with the features of metabolic syndrome (MeS) in patients with non–alcoholic fatty liver disease (NAFLD) and to establish a new noninvasive scoring system for the prediction of F...

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Autores principales: Milovanovic, Tamara, Dragasevic, Sanja, Stojkovic Lalosevic, Milica, Zgradic, Sanja, Milicic, Biljana, Dumic, Igor, Kmezic, Stefan, Saponjski, Dusan, Antic, Andrija, Markovic, Velimir, Popovic, Dragan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843527/
https://www.ncbi.nlm.nih.gov/pubmed/31627351
http://dx.doi.org/10.3390/medicina55100697
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author Milovanovic, Tamara
Dragasevic, Sanja
Stojkovic Lalosevic, Milica
Zgradic, Sanja
Milicic, Biljana
Dumic, Igor
Kmezic, Stefan
Saponjski, Dusan
Antic, Andrija
Markovic, Velimir
Popovic, Dragan
author_facet Milovanovic, Tamara
Dragasevic, Sanja
Stojkovic Lalosevic, Milica
Zgradic, Sanja
Milicic, Biljana
Dumic, Igor
Kmezic, Stefan
Saponjski, Dusan
Antic, Andrija
Markovic, Velimir
Popovic, Dragan
author_sort Milovanovic, Tamara
collection PubMed
description Background and Objectives: The aim of the study was to determine the association between presences of fatty pancreas (FP) with the features of metabolic syndrome (MeS) in patients with non–alcoholic fatty liver disease (NAFLD) and to establish a new noninvasive scoring system for the prediction of FP in patients with NAFLD. Material and Methods: 143 patients with NAFLD were classified according to FP severity grade into the two groups and evaluated for diagnostic criteria of MeS. All patients underwent sonographic examination with adiposity measurements and the liver biopsy. Liver fibrosis was evaluated semi-quantitatively according to the METAVIR scoring system and using non-invasive markers of hepatic fibrosis. Results: Waist circumference (WC) was predictive for increased risk of FP in NAFLD patients. Elevated fasting plasma glucose, total cholesterol, serum amylase and lipase levels were associated with presence of severe FP (p value = 0.052, p value = 0.007, p value = 0.014; p value = 0.024, respectively). Presence of increased amounts of mesenteric fat was associated with severe FP (p value = 0.013). The results of this study demonstrated highly significant association between NAFLD and presence of FP. The model for predicting the presence of FP was designed with probability value above 6.5. Conclusion: Pancreatic fat accumulation leads to worsening of pancreatic function which in turns exacerbates severity of metabolic syndrome associated with both, NAFLD and NAFPD.
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spelling pubmed-68435272019-11-25 Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease—A Cross Sectional Study Milovanovic, Tamara Dragasevic, Sanja Stojkovic Lalosevic, Milica Zgradic, Sanja Milicic, Biljana Dumic, Igor Kmezic, Stefan Saponjski, Dusan Antic, Andrija Markovic, Velimir Popovic, Dragan Medicina (Kaunas) Article Background and Objectives: The aim of the study was to determine the association between presences of fatty pancreas (FP) with the features of metabolic syndrome (MeS) in patients with non–alcoholic fatty liver disease (NAFLD) and to establish a new noninvasive scoring system for the prediction of FP in patients with NAFLD. Material and Methods: 143 patients with NAFLD were classified according to FP severity grade into the two groups and evaluated for diagnostic criteria of MeS. All patients underwent sonographic examination with adiposity measurements and the liver biopsy. Liver fibrosis was evaluated semi-quantitatively according to the METAVIR scoring system and using non-invasive markers of hepatic fibrosis. Results: Waist circumference (WC) was predictive for increased risk of FP in NAFLD patients. Elevated fasting plasma glucose, total cholesterol, serum amylase and lipase levels were associated with presence of severe FP (p value = 0.052, p value = 0.007, p value = 0.014; p value = 0.024, respectively). Presence of increased amounts of mesenteric fat was associated with severe FP (p value = 0.013). The results of this study demonstrated highly significant association between NAFLD and presence of FP. The model for predicting the presence of FP was designed with probability value above 6.5. Conclusion: Pancreatic fat accumulation leads to worsening of pancreatic function which in turns exacerbates severity of metabolic syndrome associated with both, NAFLD and NAFPD. MDPI 2019-10-17 /pmc/articles/PMC6843527/ /pubmed/31627351 http://dx.doi.org/10.3390/medicina55100697 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Milovanovic, Tamara
Dragasevic, Sanja
Stojkovic Lalosevic, Milica
Zgradic, Sanja
Milicic, Biljana
Dumic, Igor
Kmezic, Stefan
Saponjski, Dusan
Antic, Andrija
Markovic, Velimir
Popovic, Dragan
Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease—A Cross Sectional Study
title Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease—A Cross Sectional Study
title_full Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease—A Cross Sectional Study
title_fullStr Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease—A Cross Sectional Study
title_full_unstemmed Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease—A Cross Sectional Study
title_short Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease—A Cross Sectional Study
title_sort ultrasonographic evaluation of fatty pancreas in serbian patients with non alcoholic fatty liver disease—a cross sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843527/
https://www.ncbi.nlm.nih.gov/pubmed/31627351
http://dx.doi.org/10.3390/medicina55100697
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