Bioactive Aliphatic Polycarbonates Carrying Guanidinium Functions: An Innovative Approach for Myotonic Dystrophy Type 1 Therapy

[Image: see text] Dystrophia myotonica type 1 (DM1) results from nuclear sequestration of splicing factors by a messenger RNA (mRNA) harboring a large (CUG)(n) repeat array transcribed from the causal (CTG)(n) DNA amplification. Several compounds were previously shown to bind the (CUG)(n) RNA and re...

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Detalles Bibliográficos
Autores principales: Baroni, Alexandra, Neaga, Ioan, Delbosc, Nicolas, Wells, Mathilde, Verdy, Laetitia, Ansseau, Eugénie, Vanden Eynde, Jean Jacques, Belayew, Alexandra, Bodoki, Ede, Oprean, Radu, Hambye, Stéphanie, Blankert, Bertrand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843715/
https://www.ncbi.nlm.nih.gov/pubmed/31720515
http://dx.doi.org/10.1021/acsomega.9b02034

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