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Pharmacokinetics of the Rac/Cdc42 Inhibitor MBQ-167 in Mice by Supercritical Fluid Chromatography–Tandem Mass Spectrometry

[Image: see text] The Rho GTPases Rac and Cdc42 are potential targets against metastatic diseases. We characterized the small molecule MBQ-167 as an effective dual Rac/Cdc42 inhibitor that reduces HER2-type tumor growth and metastasis in mice by ∼90%. This study reports the pharmacokinetics and tiss...

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Detalles Bibliográficos
Autores principales:	Maldonado, María del Mar, Rosado-González, Gabriela, Bloom, Joseph, Duconge, Jorge, Ruiz-Calderón, Jean F., Hernández-O’Farrill, Eliud, Vlaar, Cornelis, Rodríguez-Orengo, José F., Dharmawardhane, Suranganie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843717/ https://www.ncbi.nlm.nih.gov/pubmed/31720502 http://dx.doi.org/10.1021/acsomega.9b01641

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