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Oral Food Challenge

Oral food challenge (OFC) is the gold standard for diagnosis of IgE-mediated and non-IgE mediated food allergy. It is usually conducted to make diagnosis, to monitor for resolution of a food allergy, or to identify the threshold of responsiveness. Clinical history and lab tests have poor diagnostic...

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Autores principales: Calvani, Mauro, Bianchi, Annamaria, Reginelli, Chiara, Peresso, Martina, Testa, Alessia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843825/
https://www.ncbi.nlm.nih.gov/pubmed/31569825
http://dx.doi.org/10.3390/medicina55100651
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author Calvani, Mauro
Bianchi, Annamaria
Reginelli, Chiara
Peresso, Martina
Testa, Alessia
author_facet Calvani, Mauro
Bianchi, Annamaria
Reginelli, Chiara
Peresso, Martina
Testa, Alessia
author_sort Calvani, Mauro
collection PubMed
description Oral food challenge (OFC) is the gold standard for diagnosis of IgE-mediated and non-IgE mediated food allergy. It is usually conducted to make diagnosis, to monitor for resolution of a food allergy, or to identify the threshold of responsiveness. Clinical history and lab tests have poor diagnostic accuracy and they are not sufficient to make a strict diagnosis of food allergy. Higher concentrations of food-specific IgE or larger allergy prick skin test wheal sizes correlate with an increased likelihood of a reaction upon ingestion. Several cut-off values, to make a diagnosis of some food allergies (e.g., milk, egg, peanut, etc.) without performing an OFC, have been suggested, but their use is still debated. The oral food challenge should be carried out by experienced physicians in a proper environment equipped for emergency, in order to carefully assess symptoms and signs and correctly manage any possible allergic reaction. This review does not intend to analyse comprehensively all the issues related to the diagnosis of food allergies, but to summarize some practical information on the OFC procedure, as reported in a recent issue by The Expert Review of Food Allergy Committee of Italian Society of Pediatric Allergy and Immunology (SIAIP).
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spelling pubmed-68438252019-11-25 Oral Food Challenge Calvani, Mauro Bianchi, Annamaria Reginelli, Chiara Peresso, Martina Testa, Alessia Medicina (Kaunas) Review Oral food challenge (OFC) is the gold standard for diagnosis of IgE-mediated and non-IgE mediated food allergy. It is usually conducted to make diagnosis, to monitor for resolution of a food allergy, or to identify the threshold of responsiveness. Clinical history and lab tests have poor diagnostic accuracy and they are not sufficient to make a strict diagnosis of food allergy. Higher concentrations of food-specific IgE or larger allergy prick skin test wheal sizes correlate with an increased likelihood of a reaction upon ingestion. Several cut-off values, to make a diagnosis of some food allergies (e.g., milk, egg, peanut, etc.) without performing an OFC, have been suggested, but their use is still debated. The oral food challenge should be carried out by experienced physicians in a proper environment equipped for emergency, in order to carefully assess symptoms and signs and correctly manage any possible allergic reaction. This review does not intend to analyse comprehensively all the issues related to the diagnosis of food allergies, but to summarize some practical information on the OFC procedure, as reported in a recent issue by The Expert Review of Food Allergy Committee of Italian Society of Pediatric Allergy and Immunology (SIAIP). MDPI 2019-09-27 /pmc/articles/PMC6843825/ /pubmed/31569825 http://dx.doi.org/10.3390/medicina55100651 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Calvani, Mauro
Bianchi, Annamaria
Reginelli, Chiara
Peresso, Martina
Testa, Alessia
Oral Food Challenge
title Oral Food Challenge
title_full Oral Food Challenge
title_fullStr Oral Food Challenge
title_full_unstemmed Oral Food Challenge
title_short Oral Food Challenge
title_sort oral food challenge
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843825/
https://www.ncbi.nlm.nih.gov/pubmed/31569825
http://dx.doi.org/10.3390/medicina55100651
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