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Oral Food Challenge
Oral food challenge (OFC) is the gold standard for diagnosis of IgE-mediated and non-IgE mediated food allergy. It is usually conducted to make diagnosis, to monitor for resolution of a food allergy, or to identify the threshold of responsiveness. Clinical history and lab tests have poor diagnostic...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843825/ https://www.ncbi.nlm.nih.gov/pubmed/31569825 http://dx.doi.org/10.3390/medicina55100651 |
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author | Calvani, Mauro Bianchi, Annamaria Reginelli, Chiara Peresso, Martina Testa, Alessia |
author_facet | Calvani, Mauro Bianchi, Annamaria Reginelli, Chiara Peresso, Martina Testa, Alessia |
author_sort | Calvani, Mauro |
collection | PubMed |
description | Oral food challenge (OFC) is the gold standard for diagnosis of IgE-mediated and non-IgE mediated food allergy. It is usually conducted to make diagnosis, to monitor for resolution of a food allergy, or to identify the threshold of responsiveness. Clinical history and lab tests have poor diagnostic accuracy and they are not sufficient to make a strict diagnosis of food allergy. Higher concentrations of food-specific IgE or larger allergy prick skin test wheal sizes correlate with an increased likelihood of a reaction upon ingestion. Several cut-off values, to make a diagnosis of some food allergies (e.g., milk, egg, peanut, etc.) without performing an OFC, have been suggested, but their use is still debated. The oral food challenge should be carried out by experienced physicians in a proper environment equipped for emergency, in order to carefully assess symptoms and signs and correctly manage any possible allergic reaction. This review does not intend to analyse comprehensively all the issues related to the diagnosis of food allergies, but to summarize some practical information on the OFC procedure, as reported in a recent issue by The Expert Review of Food Allergy Committee of Italian Society of Pediatric Allergy and Immunology (SIAIP). |
format | Online Article Text |
id | pubmed-6843825 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68438252019-11-25 Oral Food Challenge Calvani, Mauro Bianchi, Annamaria Reginelli, Chiara Peresso, Martina Testa, Alessia Medicina (Kaunas) Review Oral food challenge (OFC) is the gold standard for diagnosis of IgE-mediated and non-IgE mediated food allergy. It is usually conducted to make diagnosis, to monitor for resolution of a food allergy, or to identify the threshold of responsiveness. Clinical history and lab tests have poor diagnostic accuracy and they are not sufficient to make a strict diagnosis of food allergy. Higher concentrations of food-specific IgE or larger allergy prick skin test wheal sizes correlate with an increased likelihood of a reaction upon ingestion. Several cut-off values, to make a diagnosis of some food allergies (e.g., milk, egg, peanut, etc.) without performing an OFC, have been suggested, but their use is still debated. The oral food challenge should be carried out by experienced physicians in a proper environment equipped for emergency, in order to carefully assess symptoms and signs and correctly manage any possible allergic reaction. This review does not intend to analyse comprehensively all the issues related to the diagnosis of food allergies, but to summarize some practical information on the OFC procedure, as reported in a recent issue by The Expert Review of Food Allergy Committee of Italian Society of Pediatric Allergy and Immunology (SIAIP). MDPI 2019-09-27 /pmc/articles/PMC6843825/ /pubmed/31569825 http://dx.doi.org/10.3390/medicina55100651 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Calvani, Mauro Bianchi, Annamaria Reginelli, Chiara Peresso, Martina Testa, Alessia Oral Food Challenge |
title | Oral Food Challenge |
title_full | Oral Food Challenge |
title_fullStr | Oral Food Challenge |
title_full_unstemmed | Oral Food Challenge |
title_short | Oral Food Challenge |
title_sort | oral food challenge |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843825/ https://www.ncbi.nlm.nih.gov/pubmed/31569825 http://dx.doi.org/10.3390/medicina55100651 |
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