Recruitment of DNA Repair MRN Complex by Intrinsically Disordered Protein Domain Fused to Cas9 Improves Efficiency of CRISPR-Mediated Genome Editing

CRISPR/Cas9 is a powerful tool for genome editing in cells and organisms. Nevertheless, introducing directed templated changes by homology-directed repair (HDR) requires the cellular DNA repair machinery, such as the MRN complex (Mre11/Rad50/Nbs1). To improve the process, we tailored chimeric constr...

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Detalles Bibliográficos
Autores principales: Reuven, Nina, Adler, Julia, Broennimann, Karin, Myers, Nadav, Shaul, Yosef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843829/
https://www.ncbi.nlm.nih.gov/pubmed/31597252
http://dx.doi.org/10.3390/biom9100584

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