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Tools for the Quality Control of Pharmaceutical Heparin
Heparin is a vital pharmaceutical anticoagulant drug and remains one of the few naturally sourced pharmaceutical agents used clinically. Heparin possesses a structural order with up to four levels of complexity. These levels are subject to change based on the animal or even tissue sources that they...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843833/ https://www.ncbi.nlm.nih.gov/pubmed/31557911 http://dx.doi.org/10.3390/medicina55100636 |
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author | Devlin, Anthony Mycroft-West, Courtney Procter, Patricia Cooper, Lynsay Guimond, Scott Lima, Marcelo Yates, Edwin Skidmore, Mark |
author_facet | Devlin, Anthony Mycroft-West, Courtney Procter, Patricia Cooper, Lynsay Guimond, Scott Lima, Marcelo Yates, Edwin Skidmore, Mark |
author_sort | Devlin, Anthony |
collection | PubMed |
description | Heparin is a vital pharmaceutical anticoagulant drug and remains one of the few naturally sourced pharmaceutical agents used clinically. Heparin possesses a structural order with up to four levels of complexity. These levels are subject to change based on the animal or even tissue sources that they are extracted from, while higher levels are believed to be entirely dynamic and a product of their surrounding environments, including bound proteins and associated cations. In 2008, heparin sources were subject to a major contamination with a deadly compound—an over-sulphated chondroitin sulphate polysaccharide—that resulted in excess of 100 deaths within North America alone. In consideration of this, an arsenal of methods to screen for heparin contamination have been applied, based primarily on the detection of over-sulphated chondroitin sulphate. The targeted nature of these screening methods, for this specific contaminant, may leave contamination by other entities poorly protected against, but novel approaches, including library-based chemometric analysis in concert with a variety of spectroscopic methods, could be of great importance in combating future, potential threats. |
format | Online Article Text |
id | pubmed-6843833 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68438332019-11-25 Tools for the Quality Control of Pharmaceutical Heparin Devlin, Anthony Mycroft-West, Courtney Procter, Patricia Cooper, Lynsay Guimond, Scott Lima, Marcelo Yates, Edwin Skidmore, Mark Medicina (Kaunas) Review Heparin is a vital pharmaceutical anticoagulant drug and remains one of the few naturally sourced pharmaceutical agents used clinically. Heparin possesses a structural order with up to four levels of complexity. These levels are subject to change based on the animal or even tissue sources that they are extracted from, while higher levels are believed to be entirely dynamic and a product of their surrounding environments, including bound proteins and associated cations. In 2008, heparin sources were subject to a major contamination with a deadly compound—an over-sulphated chondroitin sulphate polysaccharide—that resulted in excess of 100 deaths within North America alone. In consideration of this, an arsenal of methods to screen for heparin contamination have been applied, based primarily on the detection of over-sulphated chondroitin sulphate. The targeted nature of these screening methods, for this specific contaminant, may leave contamination by other entities poorly protected against, but novel approaches, including library-based chemometric analysis in concert with a variety of spectroscopic methods, could be of great importance in combating future, potential threats. MDPI 2019-09-25 /pmc/articles/PMC6843833/ /pubmed/31557911 http://dx.doi.org/10.3390/medicina55100636 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Devlin, Anthony Mycroft-West, Courtney Procter, Patricia Cooper, Lynsay Guimond, Scott Lima, Marcelo Yates, Edwin Skidmore, Mark Tools for the Quality Control of Pharmaceutical Heparin |
title | Tools for the Quality Control of Pharmaceutical Heparin |
title_full | Tools for the Quality Control of Pharmaceutical Heparin |
title_fullStr | Tools for the Quality Control of Pharmaceutical Heparin |
title_full_unstemmed | Tools for the Quality Control of Pharmaceutical Heparin |
title_short | Tools for the Quality Control of Pharmaceutical Heparin |
title_sort | tools for the quality control of pharmaceutical heparin |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843833/ https://www.ncbi.nlm.nih.gov/pubmed/31557911 http://dx.doi.org/10.3390/medicina55100636 |
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