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Prognostic Value of Survival of MicroRNAs Signatures in Non-small Cell Lung Cancer

Introduction: Accumulating evidence showed that a large number of microRNAs (miRNAs) are abnormally expressed in lung cancer tissues and play critical roles in cancer development and progression. The aim of this study is to identify the differentially expressed miRNAs (DEMs) between non-small cell l...

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Autores principales: Chen, Bo, Gao, Tianshun, Yuan, Weiwei, Zhao, Weihong, Wang, Tza-Huei, Wu, Jianqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843868/
https://www.ncbi.nlm.nih.gov/pubmed/31737116
http://dx.doi.org/10.7150/jca.30336
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author Chen, Bo
Gao, Tianshun
Yuan, Weiwei
Zhao, Weihong
Wang, Tza-Huei
Wu, Jianqing
author_facet Chen, Bo
Gao, Tianshun
Yuan, Weiwei
Zhao, Weihong
Wang, Tza-Huei
Wu, Jianqing
author_sort Chen, Bo
collection PubMed
description Introduction: Accumulating evidence showed that a large number of microRNAs (miRNAs) are abnormally expressed in lung cancer tissues and play critical roles in cancer development and progression. The aim of this study is to identify the differentially expressed miRNAs (DEMs) between non-small cell lung cancer (NSCLC) and normal lung tissues, and evaluate the prognostic value and potential target gene functional enrichment of the DEMs. Materials and Methods: We first downloaded the high-throughput miRNA data from The Cancer Genome Atlas Project (TCGA) database, and subsequently analyzed the data using bioinformatics analysis including limma package in R, Kaplan-Meier curve and Log-rank method, and several online analysis tools. Results: A total of 125 DEMs and 138 DEMs were respectively identified in lung adenocarcinoma (LUAD) tissues and lung squamous cell carcinoma (LUSC) tissues compared with their matched normal tissues. Moreover, we found that the prognostic function of the eight miRNAs (miR-375, miR-148a, miR-29b-1 and miR-584 for LUAD; miR-4746, miR-326, miR-93 and miR-671 for LUSC). Furthermore, the two four-miRNA signatures were constructed and found to be an independent prognostic factor for LUAD and LUSC patients, respectively. Additionally, our results indicated that the target genes of eight miRNAs may be involved in various pathways related to NSCLC, including PI3K-Akt, TGF-beta, FoxO, Ras, GPI-anchor biosynthesis and metabolic, Rap1, HIF-1 and proteasome. Conclusion: Overall, eight miRNAs were closely correlated with survival of NSCLC patients, and the constructed two four-miRNA signatures could be respectively used as prognostic markers in LUAD and LUSC patients.
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spelling pubmed-68438682019-11-15 Prognostic Value of Survival of MicroRNAs Signatures in Non-small Cell Lung Cancer Chen, Bo Gao, Tianshun Yuan, Weiwei Zhao, Weihong Wang, Tza-Huei Wu, Jianqing J Cancer Research Paper Introduction: Accumulating evidence showed that a large number of microRNAs (miRNAs) are abnormally expressed in lung cancer tissues and play critical roles in cancer development and progression. The aim of this study is to identify the differentially expressed miRNAs (DEMs) between non-small cell lung cancer (NSCLC) and normal lung tissues, and evaluate the prognostic value and potential target gene functional enrichment of the DEMs. Materials and Methods: We first downloaded the high-throughput miRNA data from The Cancer Genome Atlas Project (TCGA) database, and subsequently analyzed the data using bioinformatics analysis including limma package in R, Kaplan-Meier curve and Log-rank method, and several online analysis tools. Results: A total of 125 DEMs and 138 DEMs were respectively identified in lung adenocarcinoma (LUAD) tissues and lung squamous cell carcinoma (LUSC) tissues compared with their matched normal tissues. Moreover, we found that the prognostic function of the eight miRNAs (miR-375, miR-148a, miR-29b-1 and miR-584 for LUAD; miR-4746, miR-326, miR-93 and miR-671 for LUSC). Furthermore, the two four-miRNA signatures were constructed and found to be an independent prognostic factor for LUAD and LUSC patients, respectively. Additionally, our results indicated that the target genes of eight miRNAs may be involved in various pathways related to NSCLC, including PI3K-Akt, TGF-beta, FoxO, Ras, GPI-anchor biosynthesis and metabolic, Rap1, HIF-1 and proteasome. Conclusion: Overall, eight miRNAs were closely correlated with survival of NSCLC patients, and the constructed two four-miRNA signatures could be respectively used as prognostic markers in LUAD and LUSC patients. Ivyspring International Publisher 2019-10-06 /pmc/articles/PMC6843868/ /pubmed/31737116 http://dx.doi.org/10.7150/jca.30336 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Chen, Bo
Gao, Tianshun
Yuan, Weiwei
Zhao, Weihong
Wang, Tza-Huei
Wu, Jianqing
Prognostic Value of Survival of MicroRNAs Signatures in Non-small Cell Lung Cancer
title Prognostic Value of Survival of MicroRNAs Signatures in Non-small Cell Lung Cancer
title_full Prognostic Value of Survival of MicroRNAs Signatures in Non-small Cell Lung Cancer
title_fullStr Prognostic Value of Survival of MicroRNAs Signatures in Non-small Cell Lung Cancer
title_full_unstemmed Prognostic Value of Survival of MicroRNAs Signatures in Non-small Cell Lung Cancer
title_short Prognostic Value of Survival of MicroRNAs Signatures in Non-small Cell Lung Cancer
title_sort prognostic value of survival of micrornas signatures in non-small cell lung cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843868/
https://www.ncbi.nlm.nih.gov/pubmed/31737116
http://dx.doi.org/10.7150/jca.30336
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