ERRα Regulates OTUB1 Expression to Promote Colorectal Cancer Cell Migration

Ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (OTUB1) is overexpressed in many cancers and plays an important role in tumor progression and metastasis. However, the molecular mechanisms underlying OTUB1 overexpression are not clear. In this study, we found that estrogen-relate...

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Autores principales: Zhou, Yi, Jia, Qingzhu, Meng, Xiaoqing, Chen, Diangang, Zhu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843886/
https://www.ncbi.nlm.nih.gov/pubmed/31737118
http://dx.doi.org/10.7150/jca.30720
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author Zhou, Yi
Jia, Qingzhu
Meng, Xiaoqing
Chen, Diangang
Zhu, Bo
author_facet Zhou, Yi
Jia, Qingzhu
Meng, Xiaoqing
Chen, Diangang
Zhu, Bo
author_sort Zhou, Yi
collection PubMed
description Ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (OTUB1) is overexpressed in many cancers and plays an important role in tumor progression and metastasis. However, the molecular mechanisms underlying OTUB1 overexpression are not clear. In this study, we found that estrogen-related receptor alpha (ERRα, also called NR3B1) binds to OTUB1 promoter and regulates its expression in colorectal cancer. Furthermore, ERRα promoted the migration of CRC cells by inducing vimentin expression via OTUB1. Our data show that OTUB1 is a novel target of ERRα and indicate that ERRα-OTUB1 signaling may play a significant role in CRC metastasis.
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spelling pubmed-68438862019-11-15 ERRα Regulates OTUB1 Expression to Promote Colorectal Cancer Cell Migration Zhou, Yi Jia, Qingzhu Meng, Xiaoqing Chen, Diangang Zhu, Bo J Cancer Research Paper Ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (OTUB1) is overexpressed in many cancers and plays an important role in tumor progression and metastasis. However, the molecular mechanisms underlying OTUB1 overexpression are not clear. In this study, we found that estrogen-related receptor alpha (ERRα, also called NR3B1) binds to OTUB1 promoter and regulates its expression in colorectal cancer. Furthermore, ERRα promoted the migration of CRC cells by inducing vimentin expression via OTUB1. Our data show that OTUB1 is a novel target of ERRα and indicate that ERRα-OTUB1 signaling may play a significant role in CRC metastasis. Ivyspring International Publisher 2019-10-06 /pmc/articles/PMC6843886/ /pubmed/31737118 http://dx.doi.org/10.7150/jca.30720 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Zhou, Yi
Jia, Qingzhu
Meng, Xiaoqing
Chen, Diangang
Zhu, Bo
ERRα Regulates OTUB1 Expression to Promote Colorectal Cancer Cell Migration
title ERRα Regulates OTUB1 Expression to Promote Colorectal Cancer Cell Migration
title_full ERRα Regulates OTUB1 Expression to Promote Colorectal Cancer Cell Migration
title_fullStr ERRα Regulates OTUB1 Expression to Promote Colorectal Cancer Cell Migration
title_full_unstemmed ERRα Regulates OTUB1 Expression to Promote Colorectal Cancer Cell Migration
title_short ERRα Regulates OTUB1 Expression to Promote Colorectal Cancer Cell Migration
title_sort errα regulates otub1 expression to promote colorectal cancer cell migration
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843886/
https://www.ncbi.nlm.nih.gov/pubmed/31737118
http://dx.doi.org/10.7150/jca.30720
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AT mengxiaoqing erraregulatesotub1expressiontopromotecolorectalcancercellmigration
AT chendiangang erraregulatesotub1expressiontopromotecolorectalcancercellmigration
AT zhubo erraregulatesotub1expressiontopromotecolorectalcancercellmigration

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