The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood–brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour a...

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Detalles Bibliográficos
Autores principales: Formicola, Beatrice, Dal Magro, Roberta, Montefusco-Pereira, Carlos V., Lehr, Claus-Michael, Koch, Marcus, Russo, Laura, Grasso, Gianvito, Deriu, Marco A., Danani, Andrea, Bourdoulous, Sandrine, Re, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844026/
https://www.ncbi.nlm.nih.gov/pubmed/31711496
http://dx.doi.org/10.1186/s12951-019-0546-3
Descripción
Sumario:We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood–brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.

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