The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood–brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour a...

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Autores principales: Formicola, Beatrice, Dal Magro, Roberta, Montefusco-Pereira, Carlos V., Lehr, Claus-Michael, Koch, Marcus, Russo, Laura, Grasso, Gianvito, Deriu, Marco A., Danani, Andrea, Bourdoulous, Sandrine, Re, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844026/
https://www.ncbi.nlm.nih.gov/pubmed/31711496
http://dx.doi.org/10.1186/s12951-019-0546-3
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author Formicola, Beatrice
Dal Magro, Roberta
Montefusco-Pereira, Carlos V.
Lehr, Claus-Michael
Koch, Marcus
Russo, Laura
Grasso, Gianvito
Deriu, Marco A.
Danani, Andrea
Bourdoulous, Sandrine
Re, Francesca
author_facet Formicola, Beatrice
Dal Magro, Roberta
Montefusco-Pereira, Carlos V.
Lehr, Claus-Michael
Koch, Marcus
Russo, Laura
Grasso, Gianvito
Deriu, Marco A.
Danani, Andrea
Bourdoulous, Sandrine
Re, Francesca
author_sort Formicola, Beatrice
collection PubMed
description We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood–brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.
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spelling pubmed-68440262019-11-15 The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB Formicola, Beatrice Dal Magro, Roberta Montefusco-Pereira, Carlos V. Lehr, Claus-Michael Koch, Marcus Russo, Laura Grasso, Gianvito Deriu, Marco A. Danani, Andrea Bourdoulous, Sandrine Re, Francesca J Nanobiotechnology Short Communication We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood–brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes. BioMed Central 2019-11-11 /pmc/articles/PMC6844026/ /pubmed/31711496 http://dx.doi.org/10.1186/s12951-019-0546-3 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Communication
Formicola, Beatrice
Dal Magro, Roberta
Montefusco-Pereira, Carlos V.
Lehr, Claus-Michael
Koch, Marcus
Russo, Laura
Grasso, Gianvito
Deriu, Marco A.
Danani, Andrea
Bourdoulous, Sandrine
Re, Francesca
The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB
title The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB
title_full The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB
title_fullStr The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB
title_full_unstemmed The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB
title_short The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB
title_sort synergistic effect of chlorotoxin-mapoe in boosting drug-loaded liposomes across the bbb
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844026/
https://www.ncbi.nlm.nih.gov/pubmed/31711496
http://dx.doi.org/10.1186/s12951-019-0546-3
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