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The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB
We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood–brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour a...
Autores principales: | Formicola, Beatrice, Dal Magro, Roberta, Montefusco-Pereira, Carlos V., Lehr, Claus-Michael, Koch, Marcus, Russo, Laura, Grasso, Gianvito, Deriu, Marco A., Danani, Andrea, Bourdoulous, Sandrine, Re, Francesca |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844026/ https://www.ncbi.nlm.nih.gov/pubmed/31711496 http://dx.doi.org/10.1186/s12951-019-0546-3 |
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