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Role of hypoxia in cancer therapy by regulating the tumor microenvironment

AIM: Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy resistance. The present study aimed to summarize the role of hypoxia in cancer therapy...

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Autores principales: Jing, Xinming, Yang, Fengming, Shao, Chuchu, Wei, Ke, Xie, Mengyan, Shen, Hua, Shu, Yongqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844052/
https://www.ncbi.nlm.nih.gov/pubmed/31711497
http://dx.doi.org/10.1186/s12943-019-1089-9
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author Jing, Xinming
Yang, Fengming
Shao, Chuchu
Wei, Ke
Xie, Mengyan
Shen, Hua
Shu, Yongqian
author_facet Jing, Xinming
Yang, Fengming
Shao, Chuchu
Wei, Ke
Xie, Mengyan
Shen, Hua
Shu, Yongqian
author_sort Jing, Xinming
collection PubMed
description AIM: Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy resistance. The present study aimed to summarize the role of hypoxia in cancer therapy by regulating the tumor microenvironment (TME) and to highlight the potential of hypoxia-targeted therapy. METHODS: Relevant published studies were retrieved from PubMed, Web of Science, and Embase using keywords such as hypoxia, cancer therapy, resistance, TME, cancer, apoptosis, DNA damage, autophagy, p53, and other similar terms. RESULTS: Recent studies have shown that hypoxia is associated with poor prognosis in patients by regulating the TME. It confers resistance to conventional therapies through a number of signaling pathways in apoptosis, autophagy, DNA damage, mitochondrial activity, p53, and drug efflux. CONCLUSION: Hypoxia targeting might be relevant to overcome hypoxia-associated resistance in cancer treatment.
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spelling pubmed-68440522019-11-15 Role of hypoxia in cancer therapy by regulating the tumor microenvironment Jing, Xinming Yang, Fengming Shao, Chuchu Wei, Ke Xie, Mengyan Shen, Hua Shu, Yongqian Mol Cancer Review AIM: Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy resistance. The present study aimed to summarize the role of hypoxia in cancer therapy by regulating the tumor microenvironment (TME) and to highlight the potential of hypoxia-targeted therapy. METHODS: Relevant published studies were retrieved from PubMed, Web of Science, and Embase using keywords such as hypoxia, cancer therapy, resistance, TME, cancer, apoptosis, DNA damage, autophagy, p53, and other similar terms. RESULTS: Recent studies have shown that hypoxia is associated with poor prognosis in patients by regulating the TME. It confers resistance to conventional therapies through a number of signaling pathways in apoptosis, autophagy, DNA damage, mitochondrial activity, p53, and drug efflux. CONCLUSION: Hypoxia targeting might be relevant to overcome hypoxia-associated resistance in cancer treatment. BioMed Central 2019-11-11 /pmc/articles/PMC6844052/ /pubmed/31711497 http://dx.doi.org/10.1186/s12943-019-1089-9 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Jing, Xinming
Yang, Fengming
Shao, Chuchu
Wei, Ke
Xie, Mengyan
Shen, Hua
Shu, Yongqian
Role of hypoxia in cancer therapy by regulating the tumor microenvironment
title Role of hypoxia in cancer therapy by regulating the tumor microenvironment
title_full Role of hypoxia in cancer therapy by regulating the tumor microenvironment
title_fullStr Role of hypoxia in cancer therapy by regulating the tumor microenvironment
title_full_unstemmed Role of hypoxia in cancer therapy by regulating the tumor microenvironment
title_short Role of hypoxia in cancer therapy by regulating the tumor microenvironment
title_sort role of hypoxia in cancer therapy by regulating the tumor microenvironment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844052/
https://www.ncbi.nlm.nih.gov/pubmed/31711497
http://dx.doi.org/10.1186/s12943-019-1089-9
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