Cargando…

The Intracellular Delivery Of Anti-HPV16 E7 scFvs Through Engineered Extracellular Vesicles Inhibits The Proliferation Of HPV-Infected Cells

PURPOSE: Single-chain variable fragments (scFvs) are one of the smallest antigen-binding units having the invaluable advantage to be expressed by a unique short open reading frame (ORF). Despite their reduced size, spontaneous cell entry of scFvs remains inefficient, hence precluding the possibility...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferrantelli, Flavia, Arenaccio, Claudia, Manfredi, Francesco, Olivetta, Eleonora, Chiozzini, Chiara, Leone, Patrizia, Percario, Zulema, Ascione, Alessandro, Flego, Michela, Di Bonito, Paola, Accardi, Luisa, Federico, Maurizio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844212/ https://www.ncbi.nlm.nih.gov/pubmed/31806970 http://dx.doi.org/10.2147/IJN.S209366

Ejemplares similares

Generation of human scFvs antibodies recognizing a prion protein epitope expressed on the surface of human lymphoblastoid cells
por: Flego, Michela, et al.
Publicado: (2007)

Antitumor HPV E7-specific CTL activity elicited by in vivo engineered exosomes produced through DNA inoculation
por: Di Bonito, Paola, et al.
Publicado: (2017)

Chicken scFvs with an Artificial Cysteine for Site-Directed Conjugation
por: Yoon, Aerin, et al.
Publicado: (2016)

Directed evolution of human scFvs in DT40 cells
por: Lim, Alfred W.Y., et al.
Publicado: (2016)

Human scFvs That Counteract Bioactivities of Staphylococcus aureus TSST-1
por: Rukkawattanakul, Thunchanok, et al.
Publicado: (2017)

Identification of Highly Specific scFvs against Total Adiponectin for Diagnostic Purposes
por: Wilton, Peter, et al.
Publicado: (2017)

A focused antibody library for selecting scFvs expressed at high levels in the cytoplasm
por: Philibert, Pascal, et al.
Publicado: (2007)

ScFvs as Allosteric Inhibitors of VEGFR-2: Novel Tools to Harness VEGF Signaling
por: Ballmer-Hofer, Kurt, et al.
Publicado: (2018)

Antibodies on demand: a fast method for the production of human scFvs with minimal amounts of antigen
por: Babel, Ingrid, et al.
Publicado: (2011)

Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain
por: Szykowska, Aleksandra, et al.
Publicado: (2021)

Selection of Anti-Sulfadimidine Specific ScFvs from a Hybridoma Cell by Eukaryotic Ribosome Display
por: Qi, Yonghua, et al.
Publicado: (2009)

Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative Phenotypes
por: Goodwin, Marshall S., et al.
Publicado: (2021)

AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy
por: Ising, Christina, et al.
Publicado: (2017)

The C-Terminal Domain of Nef(mut) Is Dispensable for the CD8(+) T Cell Immunogenicity of In Vivo Engineered Extracellular Vesicles
por: Chiozzini, Chiara, et al.
Publicado: (2021)

Long-Term Antitumor CD8(+) T Cell Immunity Induced by Endogenously Engineered Extracellular Vesicles
por: Ferrantelli, Flavia, et al.
Publicado: (2021)

CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery
por: Fennell, Brian J, et al.
Publicado: (2013)

Characterization of Anti-Citrinin Specific ScFvs Selected from Non-Immunized Mouse Splenocytes by Eukaryotic Ribosome Display
por: Cheng, Haiwei, et al.
Publicado: (2015)

Correction: AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy
por: Ising, Christina, et al.
Publicado: (2017)

A strategy to identify linker-based modules for the allosteric regulation of antibody-antigen binding affinities of different scFvs
por: Kellmann, Sarah-Jane, et al.
Publicado: (2017)

Human Monoclonal scFvs that Neutralize Fribrinogenolytic Activity of Kaouthiagin, a Zinc-Metalloproteinase in Cobra (Naja kaouthia) Venom
por: Khanongnoi, Jirawat, et al.
Publicado: (2018)

A Generic Procedure for the Isolation of pH- and Magnesium-Responsive Chicken scFvs for Downstream Purification of Human Antibodies
por: Hinz, Steffen C., et al.
Publicado: (2020)

N-Terminal Fatty Acids of NEF(MUT) Are Required for the CD8(+) T-Cell Immunogenicity of In Vivo Engineered Extracellular Vesicles
por: Chiozzini, Chiara, et al.
Publicado: (2020)

Production and expression of recombinant anti-V3 scFvs from HIV-1 clade C infected Indian patient
por: Kumar, Rajesh, et al.
Publicado: (2012)

A novel strategy for efficient production of anti-V3 human scFvs against HIV-1 clade C
por: Kumar, Rajesh, et al.
Publicado: (2012)

Generation and functional analysis of single chain variable fragments (scFvs) targeting the nucleocapsid protein of Porcine epidemic diarrhea virus
por: Wang, Fengqing, et al.
Publicado: (2022)

Latent HIV-1 is activated by exosomes from cells infected with either replication-competent or defective HIV-1
por: Arenaccio, Claudia, et al.
Publicado: (2015)

The CD8(+) T Cell-Mediated Immunity Induced by HPV-E6 Uploaded in Engineered Exosomes Is Improved by ISCOMATRIX(TM) Adjuvant
por: Manfredi, Francesco, et al.
Publicado: (2016)

HPV-E7 Delivered by Engineered Exosomes Elicits a Protective CD8(+) T Cell-Mediated Immune Response
por: Di Bonito, Paola, et al.
Publicado: (2015)

Serotype- and serogroup-specific detection of African horsesickness virus using phage displayed chicken scFvs for indirect double antibody sandwich ELISAs
por: van Wyngaardt, Wouter, et al.
Publicado: (2013)

High-volume hybridoma sequencing on the NeuroMabSeq platform enables efficient generation of recombinant monoclonal antibodies and scFvs for neuroscience research
por: Mitchell, Keith G., et al.
Publicado: (2023)

Anti-Cancer Vaccine for HPV-Associated Neoplasms: Focus on a Therapeutic HPV Vaccine Based on a Novel Tumor Antigen Delivery Method Using Endogenously Engineered Exosomes
por: Di Bonito, Paola, et al.
Publicado: (2019)

Construction of site selected phage library and characterization of anti-V3 scFvs from Indian clade C HIV-1 infected patient
por: Kumar, R, et al.
Publicado: (2012)

Isolation of nanomolar scFvs of non-human primate origin, cross-neutralizing botulinum neurotoxins A(1) and A(2) by targeting their heavy chain
por: Avril, Arnaud, et al.
Publicado: (2015)

NeuroMabSeq: high volume acquisition, processing, and curation of hybridoma sequences and their use in generating recombinant monoclonal antibodies and scFvs for neuroscience research
por: Mitchell, Keith G., et al.
Publicado: (2023)

Generation and characterization of human monoclonal single chain variable fragments (scFvs) against envelope third variable region (V3) of HIV-1 clade C
por: Kumar, Rajesh, et al.
Publicado: (2012)

A C1qTNF3 collagen domain fusion chaperones diverse secreted proteins and anti-Aβ scFvs: Applications for gene therapies
por: Moore, Brenda D., et al.
Publicado: (2023)

HIV-1 Nef Impairs Key Functional Activities in Human Macrophages through CD36 Downregulation
por: Olivetta, Eleonora, et al.
Publicado: (2014)

Intracellular human antibody fragments recognizing the VP35 protein of Zaire Ebola filovirus inhibit the protein activity
por: Flego, Michela, et al.
Publicado: (2019)

Development of a novel human phage display-derived anti-LAG3 scFv antibody targeting CD8(+) T lymphocyte exhaustion
por: Ascione, Alessandro, et al.
Publicado: (2019)

A novel intracellular antibody against the E6 oncoprotein impairs growth of human papillomavirus 16-positive tumor cells in mouse models
por: Amici, Carla, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_u8hu3dorg9h2mqc37scet70but