Development Of Novel Liposome-Encapsulated Combretastatin A4 Acylated Derivatives: Prodrug Approach For Improving Antitumor Efficacy

PURPOSE: The objective of the present study was to develop a liposomal drug delivery system based on combretastatin A4 (CA4) prodrugs modified with varying alkyl chains and investigate the in vitro drug conversion from prodrug and in vivo antitumor effect. METHODS: The prodrug of CA4 was synthesized...

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Detalles Bibliográficos
Autores principales: Gu, Yongwei, Ma, Juanjuan, Fu, Zhiqin, Xu, Youfa, Gao, Baoan, Yao, Jianzhong, Xu, Wei, Chu, Kedan, Chen, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844228/
https://www.ncbi.nlm.nih.gov/pubmed/31806973
http://dx.doi.org/10.2147/IJN.S210938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844228/
https://www.ncbi.nlm.nih.gov/pubmed/31806973
http://dx.doi.org/10.2147/IJN.S210938

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