Cargando…

Light-induced metal-free transformations of unactivated pyridotriazoles

A highly efficient and practical method for incorporation of the arylmethylpyridyl moiety into diverse molecules has been developed. This method features the transition metal-free light-induced room temperature transformation of pyridotriazoles into pyridyl carbenes, which are capable of smooth aryl...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Ziyan, Yadagiri, Dongari, Gevorgyan, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844233/
https://www.ncbi.nlm.nih.gov/pubmed/31803418
http://dx.doi.org/10.1039/c9sc02448d
Descripción
Sumario:A highly efficient and practical method for incorporation of the arylmethylpyridyl moiety into diverse molecules has been developed. This method features the transition metal-free light-induced room temperature transformation of pyridotriazoles into pyridyl carbenes, which are capable of smooth arylation, X–H insertion, and cyclopropanation reactions. The synthetic usefulness of the developed method was illustrated in a facile synthesis of biologically active molecules.