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Gain-Of-Function E76K-Mutant SHP2 Promotes Cell Proliferation, Metastasis, And Tumor Growth In Glioblastoma Through Activation Of The ERK/CREB Pathway

PURPOSE: The aim of this study was to investigate the effects of gain-of-function (GOF) E76K-mutant Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) on the biological behaviors of glioblastoma (GBM) cells, and explore the molecular mechanisms of GBM progression. METHODS: Firstl...

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Detalles Bibliográficos
Autores principales:	Yang, Fan, Xu, Mo, Wang, Shiqing, Song, Le, Yu, Dandan, Li, Yao, Cao, Rui, Xiong, Zhang, Chen, Zhijun, Zhang, Qian, Zhao, Bing, Wang, Siying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844267/ https://www.ncbi.nlm.nih.gov/pubmed/31807022 http://dx.doi.org/10.2147/OTT.S222881

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