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Measuring human carboxylesterase 2 activity in pancreatic cancer patient-derived xenografts using a ratiometric fluorescent chemosensor

Irinotecan-based therapy is a common treatment for pancreatic cancer. To elicit its anticancer activity, the drug requires first the hydrolysis action of the enzyme human carboxylesterase 2 (hCES2). It has been established that pancreatic cancer patients have various levels of hCES2, whereby patient...

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Detalles Bibliográficos
Autores principales:	Kailass, Karishma, Sadovski, Oleg, Capello, Michela, Kang, Ya'an, Fleming, Jason B., Hanash, Samir M., Beharry, Andrew A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844279/ https://www.ncbi.nlm.nih.gov/pubmed/31803422 http://dx.doi.org/10.1039/c9sc00283a

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