Cargando…

Infants of Mothers With Diabetes and Subsequent Attention Deficit Hyperactivity Disorder: A Retrospective Cohort Study

Background: Maternal diabetes mellitus (DM) increases the risk of fetal, neonatal, and long-term complications in offspring. Although this has been widely known for decades, data are limited regarding the effect of maternal pregestational and gestational diabetes on the subsequent neurodevelopmental...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Chien-Heng, Lin, Wei-De, Chou, I-Ching, Lee, Inn-Chi, Hong, Syuan-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844289/
https://www.ncbi.nlm.nih.gov/pubmed/31750280
http://dx.doi.org/10.3389/fped.2019.00452
_version_ 1783468405654814720
author Lin, Chien-Heng
Lin, Wei-De
Chou, I-Ching
Lee, Inn-Chi
Hong, Syuan-Yu
author_facet Lin, Chien-Heng
Lin, Wei-De
Chou, I-Ching
Lee, Inn-Chi
Hong, Syuan-Yu
author_sort Lin, Chien-Heng
collection PubMed
description Background: Maternal diabetes mellitus (DM) increases the risk of fetal, neonatal, and long-term complications in offspring. Although this has been widely known for decades, data are limited regarding the effect of maternal pregestational and gestational diabetes on the subsequent neurodevelopmental outcome of offspring. This study investigated whether infants of mothers with diabetes (IDMs) were associated with a risk of subsequent attention deficit hyperactivity disorder (ADHD). Objectives: We collected data from newborn infants born to mothers with gestational or pregestational diabetes at China Medical University Children's Hospital between January 1, 2006, and December 31, 2012. These patients were followed to evaluate their risk of ADHD (IDM group) compared with that for those born to mothers without DM (non-IDM group). Several assumed perinatal risk factors accompanying the IDMs were also analyzed. Results: Overall, 104 patients with average gestational ages of 36.5 weeks were included in the IDM group. Additionally, 110 patients with average gestational ages of 36.6 weeks were included in the non-IDM group. Compared with non-IDMs (reference), the overall risk of ADHD in IDMs was 2.6 [95% confidence interval (CI)P, 1.11–5.90; p = 0.03]. Furthermore, the risk of ADHD among male (OR, 3.78; 95% CI, 1.37–10.3; p = 0.001) and full-term infants [odds ratio (OR), 4.5; 95% CI, 1.16–17.6; p = 0.03] in the IDMs was higher than that in the non-IDM group. No significant differences were found among IDMs for the assumed perinatal risk factors that were analyzed. Conclusions: The study revealed a higher incidence rate of ADHD in IDMs, especially male and full-term infants. It is crucial for pediatricians to identify the early symptoms neurodevelopmental disorders, especially ADHD, in children of diabetic mothers to initiate proper assessment and treatment.
format Online
Article
Text
id pubmed-6844289
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-68442892019-11-20 Infants of Mothers With Diabetes and Subsequent Attention Deficit Hyperactivity Disorder: A Retrospective Cohort Study Lin, Chien-Heng Lin, Wei-De Chou, I-Ching Lee, Inn-Chi Hong, Syuan-Yu Front Pediatr Pediatrics Background: Maternal diabetes mellitus (DM) increases the risk of fetal, neonatal, and long-term complications in offspring. Although this has been widely known for decades, data are limited regarding the effect of maternal pregestational and gestational diabetes on the subsequent neurodevelopmental outcome of offspring. This study investigated whether infants of mothers with diabetes (IDMs) were associated with a risk of subsequent attention deficit hyperactivity disorder (ADHD). Objectives: We collected data from newborn infants born to mothers with gestational or pregestational diabetes at China Medical University Children's Hospital between January 1, 2006, and December 31, 2012. These patients were followed to evaluate their risk of ADHD (IDM group) compared with that for those born to mothers without DM (non-IDM group). Several assumed perinatal risk factors accompanying the IDMs were also analyzed. Results: Overall, 104 patients with average gestational ages of 36.5 weeks were included in the IDM group. Additionally, 110 patients with average gestational ages of 36.6 weeks were included in the non-IDM group. Compared with non-IDMs (reference), the overall risk of ADHD in IDMs was 2.6 [95% confidence interval (CI)P, 1.11–5.90; p = 0.03]. Furthermore, the risk of ADHD among male (OR, 3.78; 95% CI, 1.37–10.3; p = 0.001) and full-term infants [odds ratio (OR), 4.5; 95% CI, 1.16–17.6; p = 0.03] in the IDMs was higher than that in the non-IDM group. No significant differences were found among IDMs for the assumed perinatal risk factors that were analyzed. Conclusions: The study revealed a higher incidence rate of ADHD in IDMs, especially male and full-term infants. It is crucial for pediatricians to identify the early symptoms neurodevelopmental disorders, especially ADHD, in children of diabetic mothers to initiate proper assessment and treatment. Frontiers Media S.A. 2019-11-04 /pmc/articles/PMC6844289/ /pubmed/31750280 http://dx.doi.org/10.3389/fped.2019.00452 Text en Copyright © 2019 Lin, Lin, Chou, Lee and Hong. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Lin, Chien-Heng
Lin, Wei-De
Chou, I-Ching
Lee, Inn-Chi
Hong, Syuan-Yu
Infants of Mothers With Diabetes and Subsequent Attention Deficit Hyperactivity Disorder: A Retrospective Cohort Study
title Infants of Mothers With Diabetes and Subsequent Attention Deficit Hyperactivity Disorder: A Retrospective Cohort Study
title_full Infants of Mothers With Diabetes and Subsequent Attention Deficit Hyperactivity Disorder: A Retrospective Cohort Study
title_fullStr Infants of Mothers With Diabetes and Subsequent Attention Deficit Hyperactivity Disorder: A Retrospective Cohort Study
title_full_unstemmed Infants of Mothers With Diabetes and Subsequent Attention Deficit Hyperactivity Disorder: A Retrospective Cohort Study
title_short Infants of Mothers With Diabetes and Subsequent Attention Deficit Hyperactivity Disorder: A Retrospective Cohort Study
title_sort infants of mothers with diabetes and subsequent attention deficit hyperactivity disorder: a retrospective cohort study
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844289/
https://www.ncbi.nlm.nih.gov/pubmed/31750280
http://dx.doi.org/10.3389/fped.2019.00452
work_keys_str_mv AT linchienheng infantsofmotherswithdiabetesandsubsequentattentiondeficithyperactivitydisorderaretrospectivecohortstudy
AT linweide infantsofmotherswithdiabetesandsubsequentattentiondeficithyperactivitydisorderaretrospectivecohortstudy
AT chouiching infantsofmotherswithdiabetesandsubsequentattentiondeficithyperactivitydisorderaretrospectivecohortstudy
AT leeinnchi infantsofmotherswithdiabetesandsubsequentattentiondeficithyperactivitydisorderaretrospectivecohortstudy
AT hongsyuanyu infantsofmotherswithdiabetesandsubsequentattentiondeficithyperactivitydisorderaretrospectivecohortstudy