A novel in situ multiplex immunofluorescence panel for the assessment of tumor immunopathology and response to virotherapy in pediatric glioblastoma reveals a role for checkpoint protein inhibition

Immunotherapy with oncolytic herpes simplex virus-1 therapy offers an innovative, targeted, less-toxic approach for treating brain tumors. However, a major obstacle in maximizing oncolytic virotherapy is a lack of comprehensive understanding of the underlying mechanisms that unfold in CNS tumors/ass...

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Detalles Bibliográficos
Autores principales: Bernstock, Joshua D., Vicario, Nunzio, Rong, Li, Valdes, Pablo A., Choi, Bryan D., Chen, Jason A., DiToro, Daniel, Osorio, Diana S., Kachurak, Kara, Gessler, Florian, Johnston, James M., Atkinson, T. Prescott, Whitley, Richard J., Bag, Asim K., Gillespie, G. Yancey, Markert, James M., Maric, Dragan, Friedman, Gregory K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844311/
https://www.ncbi.nlm.nih.gov/pubmed/31741780
http://dx.doi.org/10.1080/2162402X.2019.1678921

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