Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series

With the aim to obtain novel compounds possessing both strong affinity against human carbonic anhydrases and low toxicity, we synthesised novel thiourea and sulphonamide derivatives 3, 4 and 10, and studied their in vitro inhibitory properties against human CA I, CA II and CA IX. We also evaluated t...

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Detalles Bibliográficos
Autores principales: Aspatwar, Ashok, Parvathaneni, Nanda Kumar, Barker, Harlan, Anduran, Emilie, Supuran, Claudiu T., Dubois, Ludwig, Lambin, Philippe, Parkkila, Seppo, Winum, Jean-Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844379/
https://www.ncbi.nlm.nih.gov/pubmed/31687859
http://dx.doi.org/10.1080/14756366.2019.1685510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844379/
https://www.ncbi.nlm.nih.gov/pubmed/31687859
http://dx.doi.org/10.1080/14756366.2019.1685510

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