Cargando…

Long non-coding RNAs and latent HIV – A search for novel targets for latency reversal

The latent cellular reservoir of HIV is recognized as the major barrier to cure from HIV infection. Long non-coding RNAs (lncRNAs) are more tissue and cell type-specific than protein coding genes, and may represent targets of choice for HIV latency reversal. Using two in vitro primary T-cell models,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Trypsteen, Wim, White, Cory H., Mukim, Amey, Spina, Celsa A., De Spiegelaere, Ward, Lefever, Steve, Planelles, Vicente, Bosque, Alberto, Woelk, Christopher H., Vandekerckhove, Linos, Beliakova-Bethell, Nadejda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844474/ https://www.ncbi.nlm.nih.gov/pubmed/31710657 http://dx.doi.org/10.1371/journal.pone.0224879

Ejemplares similares

Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model
por: White, Cory H., et al.
Publicado: (2016)

Replication competent virus as an important source of bias in HIV latency models utilizing single round viral constructs
por: Bonczkowski, Pawel, et al.
Publicado: (2014)

HIV Infection Elicits Differential Transcriptomic Remodeling in CD4+ T Cells with Variable Proliferative Responses to the T Cell Receptor Stimulus
por: Zhang, Xinlian, et al.
Publicado: (2023)

HIV-1 latency is established preferentially in minimally activated and non-dividing cells during productive infection of primary CD4 T cells
por: Soto, Paula C., et al.
Publicado: (2022)

Diagnostic utility of droplet digital PCR for HIV reservoir quantification
por: Trypsteen, Wim, et al.
Publicado: (2016)

Interferon-Mediated Long Non-Coding RNA Response in Macrophages in the Context of HIV
por: Schynkel, Tinus, et al.
Publicado: (2020)

An Evaluation on the Role of Non-Coding RNA in HIV Transcription and Latency: A Review
por: Ramirez, Peter W, et al.
Publicado: (2023)

Transcriptional Modulation of Human Endogenous Retroviruses in Primary CD4+ T Cells Following Vorinostat Treatment
por: White, Cory H., et al.
Publicado: (2018)

Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay
por: Trypsteen, Wim, et al.
Publicado: (2016)

Corrigendum: Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay
por: Trypsteen, Wim, et al.
Publicado: (2017)

Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals
por: Kint, Sam, et al.
Publicado: (2020)

In-depth validation of total HIV-1 DNA assays for quantification of various HIV-1 subtypes
por: Rutsaert, Sofie, et al.
Publicado: (2018)

Accurate episomal HIV 2-LTR circles quantification using optimized DNA isolation and droplet digital PCR
por: Malatinkova, Eva, et al.
Publicado: (2014)

Early treated HIV-1 positive individuals demonstrate similar restriction factor expression profile as long-term non-progressors
por: Van Hecke, Clarissa, et al.
Publicado: (2019)

Protein expression from unintegrated HIV-1 DNA introduces bias in primary in vitro post-integration latency models
por: Bonczkowski, Pawel, et al.
Publicado: (2016)

Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation
por: Kauder, Steven E., et al.
Publicado: (2009)

The use of HIV-1 integration site analysis information in clinical studies aiming at HIV cure
por: Kiselinova, Maja, et al.
Publicado: (2016)

The impact of nevirapine- versus protease inhibitor-based regimens on virological markers of HIV-1 persistence during seemingly suppressive ART
por: Kiselinova, Maja, et al.
Publicado: (2014)

Digital PCR as a tool to measure HIV persistence
por: Rutsaert, Sofie, et al.
Publicado: (2018)

Emerging PCR-Based Techniques to Study HIV-1 Reservoir Persistence
por: Lambrechts, Laurens, et al.
Publicado: (2020)

Evaluation of bisulfite kits for DNA methylation profiling in terms of DNA fragmentation and DNA recovery using digital PCR
por: Kint, Sam, et al.
Publicado: (2018)

HIV Reservoir Characterization Symposium: 19 September 2016, Ghent, Belgium
por: Malatinkova, Eva, et al.
Publicado: (2017)

On the whereabouts of SARS-CoV-2 in the human body: A systematic review
por: Trypsteen, Wim, et al.
Publicado: (2020)

Evaluating lncRNA Expression Patterns during HIV-1 Treatment Interruption
por: Schynkel, Tinus, et al.
Publicado: (2023)

Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and rectal reservoirs
por: Malatinkova, Eva, et al.
Publicado: (2015)

Homeostatic proliferation of memory T cells and expansion of the HIV-1 latent reservoir
por: Bosque, A, et al.
Publicado: (2010)

The Intact Noninducible Latent HIV-1 Reservoir Is Established in an In Vitro Primary T(CM) Cell Model of Latency
por: Sarabia, Indra, et al.
Publicado: (2021)

An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients
por: Spina, Celsa A., et al.
Publicado: (2013)

Homeostatic Proliferation Fails to Efficiently Reactivate HIV-1 Latently Infected Central Memory CD4+ T Cells
por: Bosque, Alberto, et al.
Publicado: (2011)

Monocytic-Myeloid Derived Suppressor Cells Suppress T-Cell Responses in Recovered SARS CoV2-Infected Individuals
por: Beliakova-Bethell, Nadejda, et al.
Publicado: (2022)

HIV integration sites in latently infected cell lines: evidence of ongoing replication
por: Symons, Jori, et al.
Publicado: (2017)

Comparison of Droplet Digital PCR and Seminested Real-Time PCR for Quantification of Cell-Associated HIV-1 RNA
por: Kiselinova, Maja, et al.
Publicado: (2014)

Integrated and Total HIV-1 DNA Predict Ex Vivo Viral Outgrowth
por: Kiselinova, Maja, et al.
Publicado: (2016)

Correction: Integrated and Total HIV-1 DNA Predict Ex Vivo Viral Outgrowth
por: Kiselinova, Maja, et al.
Publicado: (2016)

Erratum to: HIV integration sites in latently infected cell lines: evidence of ongoing replication
por: Symons, Jori, et al.
Publicado: (2017)

HIV-1 Latency and Latency Reversal: Does Subtype Matter?
por: Sarabia, Indra, et al.
Publicado: (2019)

Janus kinase inhibition suppresses PKC-induced cytokine release without affecting HIV-1 latency reversal ex vivo
por: Spivak, Adam M., et al.
Publicado: (2016)

Structure-Activity Relationship Analysis of Benzotriazine Analogues as HIV-1 Latency-Reversing Agents
por: Sorensen, Eric S., et al.
Publicado: (2020)

Mycobacterium tuberculosis reactivates latent HIV-1 in T cells in vitro
por: Larson, Erica C., et al.
Publicado: (2017)

Beyond the Syndemic of Opioid Use Disorders and HIV: The Impact of Opioids on Viral Reservoirs
por: Trunfio, Mattia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_obblk7ptl1n7l7hcks5u4vpmij