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A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea – dose optimization, clinical outcomes, and CD4+ T cell responses

Enterotoxigenic Escherichia coli (ETEC) are a common cause of diarrheal illness in young children and travelers. There is yet no licensed broadly protective vaccine against ETEC. One promising vaccine development strategy is to target strains expressing the heat-stable toxin (ST), particularly the h...

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Detalles Bibliográficos
Autores principales:	Sakkestad, Sunniva Todnem, Steinsland, Hans, Skrede, Steinar, Lillebø, Kristine, Skutlaberg, Dag Harald, Guttormsen, Anne Berit, Zavialov, Anton, Paavilainen, Sari, Søyland, Hanne, Sævik, Marianne, Heien, Astrid Rykkje, Tellevik, Marit Gjerde, Barry, Eileen, Langeland, Nina, Sommerfelt, Halvor, Hanevik, Kurt
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844497/ https://www.ncbi.nlm.nih.gov/pubmed/31665141 http://dx.doi.org/10.1371/journal.pntd.0007823

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