HIF1A and NFAT5 coordinate Na(+)-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting

Infection and inflammation are able to induce diet-independent Na(+)-accumulation without commensurate water retention in afflicted tissues, which favors the pro-inflammatory activation of mouse macrophages and augments their antibacterial and antiparasitic activity. While Na(+)-boosted host defense...

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Detalles Bibliográficos
Autores principales: Neubert, Patrick, Weichselbaum, Andrea, Reitinger, Carmen, Schatz, Valentin, Schröder, Agnes, Ferdinand, John R., Simon, Michaela, Bär, Anna-Lorena, Brochhausen, Christoph, Gerlach, Roman G., Tomiuk, Stefan, Hammer, Karin, Wagner, Stefan, van Zandbergen, Ger, Binger, Katrina J., Müller, Dominik N., Kitada, Kento, Clatworthy, Menna R., Kurts, Christian, Titze, Jens, Abdullah, Zeinab, Jantsch, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844503/
https://www.ncbi.nlm.nih.gov/pubmed/30982460
http://dx.doi.org/10.1080/15548627.2019.1596483

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