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The Potential Markers of Circulating microRNAs and long non-coding RNAs in Alzheimer's Disease

Alzheimer’s disease (AD) is a neurodegenerative disorder and one of the leading causes of disability and mortality in the late life with no curative treatment currently. Thus, it is urgently to establish sensitive and non-invasive biomarkers for AD diagnosis, particularly in the early stage. Recentl...

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Autores principales: Zhao, Yanfang, Zhang, Yuan, Zhang, Lei, Dong, Yanhan, Ji, Hongfang, Shen, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844586/
https://www.ncbi.nlm.nih.gov/pubmed/31788340
http://dx.doi.org/10.14336/AD.2018.1105
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author Zhao, Yanfang
Zhang, Yuan
Zhang, Lei
Dong, Yanhan
Ji, Hongfang
Shen, Liang
author_facet Zhao, Yanfang
Zhang, Yuan
Zhang, Lei
Dong, Yanhan
Ji, Hongfang
Shen, Liang
author_sort Zhao, Yanfang
collection PubMed
description Alzheimer’s disease (AD) is a neurodegenerative disorder and one of the leading causes of disability and mortality in the late life with no curative treatment currently. Thus, it is urgently to establish sensitive and non-invasive biomarkers for AD diagnosis, particularly in the early stage. Recently, emerging number of microRNAs (miRNAs) and long-noncoding RNAs (lncRNAs) are considered as effective biomarkers in various diseases as they possess characteristics of stable, resistant to RNAase digestion and many extreme conditions in circulatory fluid. This review highlights recent advances in the identification of the aberrantly expressed miRNAs and lncRNAs in circulatory network for detection of AD. We summarized the abnormal expressed miRNAs in blood and cerebrospinal fluid (CSF), and detailed discussed the functions and molecular mechanism of serum or plasma miRNAs-miR-195, miR-155, miR-34a, miR-9, miR-206, miR-125b and miR-29 in the regulation of AD progression. In addition, we also elaborated the role of circulating lncRNA major including beta-site APP cleaving enzyme 1 (BACE1) and its antisense lncRNA BACE1-AS in AD pathological advancement. In brief, confirming the aberrantly expressed circulating miRNAs and lncRNAs will provide an effective testing tools for treatment of AD in the future.
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spelling pubmed-68445862019-12-01 The Potential Markers of Circulating microRNAs and long non-coding RNAs in Alzheimer's Disease Zhao, Yanfang Zhang, Yuan Zhang, Lei Dong, Yanhan Ji, Hongfang Shen, Liang Aging Dis Review Alzheimer’s disease (AD) is a neurodegenerative disorder and one of the leading causes of disability and mortality in the late life with no curative treatment currently. Thus, it is urgently to establish sensitive and non-invasive biomarkers for AD diagnosis, particularly in the early stage. Recently, emerging number of microRNAs (miRNAs) and long-noncoding RNAs (lncRNAs) are considered as effective biomarkers in various diseases as they possess characteristics of stable, resistant to RNAase digestion and many extreme conditions in circulatory fluid. This review highlights recent advances in the identification of the aberrantly expressed miRNAs and lncRNAs in circulatory network for detection of AD. We summarized the abnormal expressed miRNAs in blood and cerebrospinal fluid (CSF), and detailed discussed the functions and molecular mechanism of serum or plasma miRNAs-miR-195, miR-155, miR-34a, miR-9, miR-206, miR-125b and miR-29 in the regulation of AD progression. In addition, we also elaborated the role of circulating lncRNA major including beta-site APP cleaving enzyme 1 (BACE1) and its antisense lncRNA BACE1-AS in AD pathological advancement. In brief, confirming the aberrantly expressed circulating miRNAs and lncRNAs will provide an effective testing tools for treatment of AD in the future. JKL International LLC 2019-12-01 /pmc/articles/PMC6844586/ /pubmed/31788340 http://dx.doi.org/10.14336/AD.2018.1105 Text en Copyright: © 2019 Zhao et al. http://creativecommons.org/licenses/by/2.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Review
Zhao, Yanfang
Zhang, Yuan
Zhang, Lei
Dong, Yanhan
Ji, Hongfang
Shen, Liang
The Potential Markers of Circulating microRNAs and long non-coding RNAs in Alzheimer's Disease
title The Potential Markers of Circulating microRNAs and long non-coding RNAs in Alzheimer's Disease
title_full The Potential Markers of Circulating microRNAs and long non-coding RNAs in Alzheimer's Disease
title_fullStr The Potential Markers of Circulating microRNAs and long non-coding RNAs in Alzheimer's Disease
title_full_unstemmed The Potential Markers of Circulating microRNAs and long non-coding RNAs in Alzheimer's Disease
title_short The Potential Markers of Circulating microRNAs and long non-coding RNAs in Alzheimer's Disease
title_sort potential markers of circulating micrornas and long non-coding rnas in alzheimer's disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844586/
https://www.ncbi.nlm.nih.gov/pubmed/31788340
http://dx.doi.org/10.14336/AD.2018.1105
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