Stop codons and the +4 nucleotide may influence the efficiency of G418 in rescuing nonsense mutations of the HERG gene

The importance of the local sequence context in determining how efficiently aminoglycosides rescue nonsense mutations has been established previously in disease models. Different stop codons appear to facilitate the termination process with differing efficiencies. Furthermore, the efficiency with wh...

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Detalles Bibliográficos
Autores principales: Yu, Haiyun, Meng, Yanhai, Zhang, Shuhong, Tian, Chen, Wu, Fang, Li, Ning, Li, Qiuyang, Jin, Yulan, Pu, Jielin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844634/
https://www.ncbi.nlm.nih.gov/pubmed/31573043
http://dx.doi.org/10.3892/ijmm.2019.4360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844634/
https://www.ncbi.nlm.nih.gov/pubmed/31573043
http://dx.doi.org/10.3892/ijmm.2019.4360

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