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Cerebellar climbing fibers encode expected reward size

Climbing fiber inputs to the cerebellum encode error signals that instruct learning. Recently, evidence has accumulated to suggest that the cerebellum is also involved in the processing of reward. To study how rewarding events are encoded, we recorded the activity of climbing fibers when monkeys wer...

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Detalles Bibliográficos
Autores principales: Larry, Noga, Yarkoni, Merav, Lixenberg, Adi, Joshua, Mati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844644/
https://www.ncbi.nlm.nih.gov/pubmed/31661073
http://dx.doi.org/10.7554/eLife.46870
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author Larry, Noga
Yarkoni, Merav
Lixenberg, Adi
Joshua, Mati
author_facet Larry, Noga
Yarkoni, Merav
Lixenberg, Adi
Joshua, Mati
author_sort Larry, Noga
collection PubMed
description Climbing fiber inputs to the cerebellum encode error signals that instruct learning. Recently, evidence has accumulated to suggest that the cerebellum is also involved in the processing of reward. To study how rewarding events are encoded, we recorded the activity of climbing fibers when monkeys were engaged in an eye movement task. At the beginning of each trial, the monkeys were cued to the size of the reward that would be delivered upon successful completion of the trial. Climbing fiber activity increased when the monkeys were presented with a cue indicating a large reward, but not a small reward. Reward size did not modulate activity at reward delivery or during eye movements. Comparison between climbing fiber and simple spike activity indicated different interactions for coding of movement and reward. These results indicate that climbing fibers encode the expected reward size and suggest a general role of the cerebellum in associative learning beyond error correction.
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spelling pubmed-68446442019-11-13 Cerebellar climbing fibers encode expected reward size Larry, Noga Yarkoni, Merav Lixenberg, Adi Joshua, Mati eLife Neuroscience Climbing fiber inputs to the cerebellum encode error signals that instruct learning. Recently, evidence has accumulated to suggest that the cerebellum is also involved in the processing of reward. To study how rewarding events are encoded, we recorded the activity of climbing fibers when monkeys were engaged in an eye movement task. At the beginning of each trial, the monkeys were cued to the size of the reward that would be delivered upon successful completion of the trial. Climbing fiber activity increased when the monkeys were presented with a cue indicating a large reward, but not a small reward. Reward size did not modulate activity at reward delivery or during eye movements. Comparison between climbing fiber and simple spike activity indicated different interactions for coding of movement and reward. These results indicate that climbing fibers encode the expected reward size and suggest a general role of the cerebellum in associative learning beyond error correction. eLife Sciences Publications, Ltd 2019-10-29 /pmc/articles/PMC6844644/ /pubmed/31661073 http://dx.doi.org/10.7554/eLife.46870 Text en © 2019, Larry et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Larry, Noga
Yarkoni, Merav
Lixenberg, Adi
Joshua, Mati
Cerebellar climbing fibers encode expected reward size
title Cerebellar climbing fibers encode expected reward size
title_full Cerebellar climbing fibers encode expected reward size
title_fullStr Cerebellar climbing fibers encode expected reward size
title_full_unstemmed Cerebellar climbing fibers encode expected reward size
title_short Cerebellar climbing fibers encode expected reward size
title_sort cerebellar climbing fibers encode expected reward size
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844644/
https://www.ncbi.nlm.nih.gov/pubmed/31661073
http://dx.doi.org/10.7554/eLife.46870
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