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Cerebellar climbing fibers encode expected reward size
Climbing fiber inputs to the cerebellum encode error signals that instruct learning. Recently, evidence has accumulated to suggest that the cerebellum is also involved in the processing of reward. To study how rewarding events are encoded, we recorded the activity of climbing fibers when monkeys wer...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844644/ https://www.ncbi.nlm.nih.gov/pubmed/31661073 http://dx.doi.org/10.7554/eLife.46870 |
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author | Larry, Noga Yarkoni, Merav Lixenberg, Adi Joshua, Mati |
author_facet | Larry, Noga Yarkoni, Merav Lixenberg, Adi Joshua, Mati |
author_sort | Larry, Noga |
collection | PubMed |
description | Climbing fiber inputs to the cerebellum encode error signals that instruct learning. Recently, evidence has accumulated to suggest that the cerebellum is also involved in the processing of reward. To study how rewarding events are encoded, we recorded the activity of climbing fibers when monkeys were engaged in an eye movement task. At the beginning of each trial, the monkeys were cued to the size of the reward that would be delivered upon successful completion of the trial. Climbing fiber activity increased when the monkeys were presented with a cue indicating a large reward, but not a small reward. Reward size did not modulate activity at reward delivery or during eye movements. Comparison between climbing fiber and simple spike activity indicated different interactions for coding of movement and reward. These results indicate that climbing fibers encode the expected reward size and suggest a general role of the cerebellum in associative learning beyond error correction. |
format | Online Article Text |
id | pubmed-6844644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-68446442019-11-13 Cerebellar climbing fibers encode expected reward size Larry, Noga Yarkoni, Merav Lixenberg, Adi Joshua, Mati eLife Neuroscience Climbing fiber inputs to the cerebellum encode error signals that instruct learning. Recently, evidence has accumulated to suggest that the cerebellum is also involved in the processing of reward. To study how rewarding events are encoded, we recorded the activity of climbing fibers when monkeys were engaged in an eye movement task. At the beginning of each trial, the monkeys were cued to the size of the reward that would be delivered upon successful completion of the trial. Climbing fiber activity increased when the monkeys were presented with a cue indicating a large reward, but not a small reward. Reward size did not modulate activity at reward delivery or during eye movements. Comparison between climbing fiber and simple spike activity indicated different interactions for coding of movement and reward. These results indicate that climbing fibers encode the expected reward size and suggest a general role of the cerebellum in associative learning beyond error correction. eLife Sciences Publications, Ltd 2019-10-29 /pmc/articles/PMC6844644/ /pubmed/31661073 http://dx.doi.org/10.7554/eLife.46870 Text en © 2019, Larry et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Larry, Noga Yarkoni, Merav Lixenberg, Adi Joshua, Mati Cerebellar climbing fibers encode expected reward size |
title | Cerebellar climbing fibers encode expected reward size |
title_full | Cerebellar climbing fibers encode expected reward size |
title_fullStr | Cerebellar climbing fibers encode expected reward size |
title_full_unstemmed | Cerebellar climbing fibers encode expected reward size |
title_short | Cerebellar climbing fibers encode expected reward size |
title_sort | cerebellar climbing fibers encode expected reward size |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844644/ https://www.ncbi.nlm.nih.gov/pubmed/31661073 http://dx.doi.org/10.7554/eLife.46870 |
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