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SOLUBLE INTERCELLULAR ADHESION MOLECULE (SICAM-1) AS A BIOMARKER OF VASCULAR COGNITIVE IMPAIRMENT IN OLDER ADULTS
Background: Endothelial dysfunction and subsequent inflammation contribute to the development of vascular cognitive impairment (VCI). Soluble intercellular adhesion molecule-1 (sICAM-1) is upregulated in endothelial dysfunction and promotes an inflammatory response; however, the relationship between...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844660/ http://dx.doi.org/10.1093/geroni/igz038.959 |
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author | Arenas, Rosalinda Sanchez Gregory, Michael A Manuel-Apolinar, Leticia |
author_facet | Arenas, Rosalinda Sanchez Gregory, Michael A Manuel-Apolinar, Leticia |
author_sort | Arenas, Rosalinda Sanchez |
collection | PubMed |
description | Background: Endothelial dysfunction and subsequent inflammation contribute to the development of vascular cognitive impairment (VCI). Soluble intercellular adhesion molecule-1 (sICAM-1) is upregulated in endothelial dysfunction and promotes an inflammatory response; however, the relationship between sICAM-1 and VCI remains equivocal. Objective: To determine whether sICAM-1 contributes to the prediction of VCI. Methods: Community-dwelling older adults (n=172) from the “Cohort of Obesity, Sarcopenia and Frailty of Older Mexican Adults” (COSFOMA) study were identified as VCI or controls using standard neuropsychological evaluations and neuroimaging. sICAM-1 was quantified using ELISA, and multivariate logistic regression determined the association between sICAM-1 and VCI. Results: 31 VCI cases were identified. sICAM-1 was higher in VCI [VCI: 450.7 (241.6) ng/ml vs. Control: 296.9 (140.9) ng/ml]. sICAM-1 concentrations above the 90th percentile (464.1 ng/mL) was associated with VCI group membership in all models [OR = 6.9 (95% CI: 1.1- 42.2)]. The final saturated model explained 64% of the variance in VCI group membership. Conclusion: High concentrations of sICAM-1 are independently associated with VCI group membership. Efforts to further characterize the relationship between indices of endothelial dysfunction and pathological changes to the aging brain should be further pursued. |
format | Online Article Text |
id | pubmed-6844660 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-68446602019-11-18 SOLUBLE INTERCELLULAR ADHESION MOLECULE (SICAM-1) AS A BIOMARKER OF VASCULAR COGNITIVE IMPAIRMENT IN OLDER ADULTS Arenas, Rosalinda Sanchez Gregory, Michael A Manuel-Apolinar, Leticia Innov Aging Session 1310 (Poster) Background: Endothelial dysfunction and subsequent inflammation contribute to the development of vascular cognitive impairment (VCI). Soluble intercellular adhesion molecule-1 (sICAM-1) is upregulated in endothelial dysfunction and promotes an inflammatory response; however, the relationship between sICAM-1 and VCI remains equivocal. Objective: To determine whether sICAM-1 contributes to the prediction of VCI. Methods: Community-dwelling older adults (n=172) from the “Cohort of Obesity, Sarcopenia and Frailty of Older Mexican Adults” (COSFOMA) study were identified as VCI or controls using standard neuropsychological evaluations and neuroimaging. sICAM-1 was quantified using ELISA, and multivariate logistic regression determined the association between sICAM-1 and VCI. Results: 31 VCI cases were identified. sICAM-1 was higher in VCI [VCI: 450.7 (241.6) ng/ml vs. Control: 296.9 (140.9) ng/ml]. sICAM-1 concentrations above the 90th percentile (464.1 ng/mL) was associated with VCI group membership in all models [OR = 6.9 (95% CI: 1.1- 42.2)]. The final saturated model explained 64% of the variance in VCI group membership. Conclusion: High concentrations of sICAM-1 are independently associated with VCI group membership. Efforts to further characterize the relationship between indices of endothelial dysfunction and pathological changes to the aging brain should be further pursued. Oxford University Press 2019-11-08 /pmc/articles/PMC6844660/ http://dx.doi.org/10.1093/geroni/igz038.959 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Session 1310 (Poster) Arenas, Rosalinda Sanchez Gregory, Michael A Manuel-Apolinar, Leticia SOLUBLE INTERCELLULAR ADHESION MOLECULE (SICAM-1) AS A BIOMARKER OF VASCULAR COGNITIVE IMPAIRMENT IN OLDER ADULTS |
title | SOLUBLE INTERCELLULAR ADHESION MOLECULE (SICAM-1) AS A BIOMARKER OF VASCULAR COGNITIVE IMPAIRMENT IN OLDER ADULTS |
title_full | SOLUBLE INTERCELLULAR ADHESION MOLECULE (SICAM-1) AS A BIOMARKER OF VASCULAR COGNITIVE IMPAIRMENT IN OLDER ADULTS |
title_fullStr | SOLUBLE INTERCELLULAR ADHESION MOLECULE (SICAM-1) AS A BIOMARKER OF VASCULAR COGNITIVE IMPAIRMENT IN OLDER ADULTS |
title_full_unstemmed | SOLUBLE INTERCELLULAR ADHESION MOLECULE (SICAM-1) AS A BIOMARKER OF VASCULAR COGNITIVE IMPAIRMENT IN OLDER ADULTS |
title_short | SOLUBLE INTERCELLULAR ADHESION MOLECULE (SICAM-1) AS A BIOMARKER OF VASCULAR COGNITIVE IMPAIRMENT IN OLDER ADULTS |
title_sort | soluble intercellular adhesion molecule (sicam-1) as a biomarker of vascular cognitive impairment in older adults |
topic | Session 1310 (Poster) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844660/ http://dx.doi.org/10.1093/geroni/igz038.959 |
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