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EFFECTS OF RESISTANCE EXERCISE TRAINING ON ENDOTHELIAL FUNCTION AND MUSCLE PERFUSION IN OLDER ADULTS WITH DIABETES

BACKGROUND: Sarcopenia contributes to frailty, disability, and dependence in older adults, and is accelerated by Type 2 Diabetes Mellitus (T2DM). In addition to its direct role in increasing muscle mass, progressive resistance exercise training (PRET) may also reduce sarcopenia by improving endothel...

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Autores principales: Randolph, Amanda, Moro, Tatiana, Odejimi, Adetutu, Rasmussen, Blake, Volpi, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844782/
http://dx.doi.org/10.1093/geroni/igz038.3454
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author Randolph, Amanda
Moro, Tatiana
Odejimi, Adetutu
Rasmussen, Blake
Volpi, Elena
author_facet Randolph, Amanda
Moro, Tatiana
Odejimi, Adetutu
Rasmussen, Blake
Volpi, Elena
author_sort Randolph, Amanda
collection PubMed
description BACKGROUND: Sarcopenia contributes to frailty, disability, and dependence in older adults, and is accelerated by Type 2 Diabetes Mellitus (T2DM). In addition to its direct role in increasing muscle mass, progressive resistance exercise training (PRET) may also reduce sarcopenia by improving endothelial function and muscle perfusion. METHODS: Fifteen older adults with uncomplicated and well-controlled T2DM participated in a PRET program 3 times weekly for 3 months. Prior to and immediately following the intervention, flow-mediated dilation testing was performed to assess large vessel endothelial function via ultrasound and muscle perfusion via near-infrared spectroscopy (NIRS). RESULTS: Preliminary ultrasound data from 9 subjects show a significant increase (5.21% to 8.73%, p=0.0448) in percent flow mediated dilation (%FMD), suggesting a modest improvement in endothelial function after 3 months’ PRET. Preliminary NIRS data from 7 subjects showed no significant changes in oxygen saturation or reperfusion rates as a result of the intervention. CONCLUSION: Our preliminary data indicate that, in older adults with T2DM, 3 months’ PRET is associated with modestly improved endothelial function in large vessels (as demonstrated by a significant increase in %FMD), but does not appear to be associated with improvements in muscle perfusion
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spelling pubmed-68447822019-11-18 EFFECTS OF RESISTANCE EXERCISE TRAINING ON ENDOTHELIAL FUNCTION AND MUSCLE PERFUSION IN OLDER ADULTS WITH DIABETES Randolph, Amanda Moro, Tatiana Odejimi, Adetutu Rasmussen, Blake Volpi, Elena Innov Aging Session Lb3620 (Late Breaking Poster) BACKGROUND: Sarcopenia contributes to frailty, disability, and dependence in older adults, and is accelerated by Type 2 Diabetes Mellitus (T2DM). In addition to its direct role in increasing muscle mass, progressive resistance exercise training (PRET) may also reduce sarcopenia by improving endothelial function and muscle perfusion. METHODS: Fifteen older adults with uncomplicated and well-controlled T2DM participated in a PRET program 3 times weekly for 3 months. Prior to and immediately following the intervention, flow-mediated dilation testing was performed to assess large vessel endothelial function via ultrasound and muscle perfusion via near-infrared spectroscopy (NIRS). RESULTS: Preliminary ultrasound data from 9 subjects show a significant increase (5.21% to 8.73%, p=0.0448) in percent flow mediated dilation (%FMD), suggesting a modest improvement in endothelial function after 3 months’ PRET. Preliminary NIRS data from 7 subjects showed no significant changes in oxygen saturation or reperfusion rates as a result of the intervention. CONCLUSION: Our preliminary data indicate that, in older adults with T2DM, 3 months’ PRET is associated with modestly improved endothelial function in large vessels (as demonstrated by a significant increase in %FMD), but does not appear to be associated with improvements in muscle perfusion Oxford University Press 2019-11-08 /pmc/articles/PMC6844782/ http://dx.doi.org/10.1093/geroni/igz038.3454 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Session Lb3620 (Late Breaking Poster)
Randolph, Amanda
Moro, Tatiana
Odejimi, Adetutu
Rasmussen, Blake
Volpi, Elena
EFFECTS OF RESISTANCE EXERCISE TRAINING ON ENDOTHELIAL FUNCTION AND MUSCLE PERFUSION IN OLDER ADULTS WITH DIABETES
title EFFECTS OF RESISTANCE EXERCISE TRAINING ON ENDOTHELIAL FUNCTION AND MUSCLE PERFUSION IN OLDER ADULTS WITH DIABETES
title_full EFFECTS OF RESISTANCE EXERCISE TRAINING ON ENDOTHELIAL FUNCTION AND MUSCLE PERFUSION IN OLDER ADULTS WITH DIABETES
title_fullStr EFFECTS OF RESISTANCE EXERCISE TRAINING ON ENDOTHELIAL FUNCTION AND MUSCLE PERFUSION IN OLDER ADULTS WITH DIABETES
title_full_unstemmed EFFECTS OF RESISTANCE EXERCISE TRAINING ON ENDOTHELIAL FUNCTION AND MUSCLE PERFUSION IN OLDER ADULTS WITH DIABETES
title_short EFFECTS OF RESISTANCE EXERCISE TRAINING ON ENDOTHELIAL FUNCTION AND MUSCLE PERFUSION IN OLDER ADULTS WITH DIABETES
title_sort effects of resistance exercise training on endothelial function and muscle perfusion in older adults with diabetes
topic Session Lb3620 (Late Breaking Poster)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844782/
http://dx.doi.org/10.1093/geroni/igz038.3454
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