Cargando…

GENOME-WIDE META-ANALYSIS SUPPORTS HETEROGENEITY IN POLYGENIC ARCHITECTURE OF DISABILITY

Disability and frailty increase steeply with age after midlife. They comprise broad, non-specific aging-related health/well-being declines. Understanding the molecular mechanisms of these declines could help in combating processes related to intrinsic aging. We performed genome-wide meta-analysis of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kulminski, Alexander, Kang, Chansuk, Loika, Yury, Stallard, Eric, Culminskaya, Irina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Session 820 (Poster)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844811/ http://dx.doi.org/10.1093/geroni/igz038.335

Ejemplares similares

QUANTIFICATIONS OF BIOLOGICAL AGING PREDICT DISABILITY AND MORTALITY IN OLDER ADULTS IN THE DUKE EPESE
por: Parker, Daniel C, et al.
Publicado: (2019)

THE ROLE OF PERCEIVED SOCIAL SUPPORT AND PRUDENT DIET INTAKE ON ALLOSTATIC LOAD AMONG OLDER ADULTS
por: D'Amico, Danielle, et al.
Publicado: (2019)

EXOME-WIDE STUDY IDENTIFIED 12 PLEIOTROPIC LOCI ASSOCIATED WITH ALZHEIMER’S AND CARDIOVASCULAR DISEASE RISKS
por: Loika, Yury, et al.
Publicado: (2022)

WHOLE-BODY TAU-KNOCKOUT MICE DEVELOP AGE-ASSOCIATED METABOLIC DYSFUNCTION AND OBESITY
por: Baeuerle, Eric, et al.
Publicado: (2019)

THE ASSOCIATION BETWEEN D3CR MUSCLE MASS AND MORTALITY IN COMMUNITY-DWELLING OLDER MEN
por: Cawthon, Peggy M, et al.
Publicado: (2019)

FRAILTY ASSESSMENT BASED ON THE QUALITY OF DAILY WALKING
por: Kumar, Danya Pradeep, et al.
Publicado: (2019)

ANTIBIOTIC EXPOSURE IN LONG-TERM CARE FACILITIES IS ASSOCIATED WITH URINARY MICROBIOME PERTURBATIONS
por: Schell, Brent R, et al.
Publicado: (2019)

DIFFERENTIAL EFFECTS OF VARYING DOSES OF DIETARY NITRATE ON MUSCLE FUNCTION AND BLOOD PRESSURE IN OLDER SUBJECTS
por: Coggan, Andrew R, et al.
Publicado: (2019)

CORRELATION BETWEEN FRAILTY AND DNA DAMAGE IN HEMATOPOIETIC STEM CELLS: A PILOT STUDY
por: Mazzola, Paolo, et al.
Publicado: (2019)

THE EFFECTS OF FRAILTY, POLYPHARMACY, AND COGNITION ON HEALTH OUTCOMES: A STUDY ON INTERRAI RESIDENTIAL CARE DATA
por: Zou, Macy, et al.
Publicado: (2019)

HAND2 TRANSCRIPTION FACTOR ENHANCES NMJ ORGANIZATION AND FUNCTION IN OLD MICE
por: Rodrigues, Anna Carolina Zaia, et al.
Publicado: (2019)

LOSS OF HYPOXIA SIGNALING LIMITS SKELETAL MUSCLE RESPONSE TO AEROBIC EXERCISE IN AGING
por: Endo, Yori, et al.
Publicado: (2019)

PROTEIN SUPPLEMENTATION DOES NOT RESCUE MUSCLE MASS AND FUNCTION–HEAVY RESISTANCE TRAINING IS REQUIRED
por: Holm, Lars, et al.
Publicado: (2019)

GAIT SLOWING AMONG FRAIL OLDER ADULTS: IS HIGHER DOPAMINERGIC SIGNALING PROTECTIVE?
por: Rosano, Caterina, et al.
Publicado: (2019)

AGE, SEX, AND FRAILTY INFLUENCE AGE-DEPENDENT CHANGES IN VENTRICULAR STRUCTURE AND FUNCTION IN C57BL/6 MICE
por: Howlett, Susan E, et al.
Publicado: (2019)

THE ASSOCIATION BETWEEN MODERATE-TO-VIGOROUS PHYSICAL ACTIVITY AND MUSCLE OXIDATIVE CAPACITY IN OLDER ADULTS
por: Adelnia, Fatemeh, et al.
Publicado: (2019)

THE PROBLEM OF INTEGRATING OF BIOLOGICAL AND CLINICAL MARKERS OF AGEING
por: Mitnitski, Arnold, et al.
Publicado: (2019)

METABOLOMICS IN MEN WITH DISTINCT INFLAMMATION TRAJECTORIES FOLLOWING HIP FRACTURE REVEAL RESPONSE MECHANISMS
por: Salimi, Shabnam, et al.
Publicado: (2019)

WHOLE-BODY MRI TO ASSESS SUBCLINICAL CARDIOVASCULAR DISEASE AND FRAILTY DEVELOPMENT
por: Ambale-Venkatesh, Bharath, et al.
Publicado: (2019)

AGE-RELATED CHANGES TO MACROPHAGES AFFECT FRACTURE HEALING
por: Clark, Daniel, et al.
Publicado: (2019)

SUPPRESSION OF GHRELIN SIGNALING EXACERBATES ULCERATIVE COLITIS IN OLDER MICE
por: Wu, Chia-Shan, et al.
Publicado: (2019)

β-GPA: AN AMPK ACTIVATOR WITH POTENTIAL EFFECTS ON HEALTHSPAN AND FUNCTION
por: Dorigatti, Jonathan, et al.
Publicado: (2019)

LOW-INTENSITY EXERCISE ENHANCES MUSCULAR ANDROGEN/ANDROGEN RECEPTOR TO INHIBIT MYOSTATIN PATHWAY
por: Son, Bo-Kyung, et al.
Publicado: (2019)

CASE STUDY EXEMPLAR OF DETECTING SEVERE DIASTOLIC DYSFUNCTION USING BALLISTOCARDIOGRAM
por: Despins, Laurel A, et al.
Publicado: (2019)

Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency
por: Kulminski, Alexander M., et al.
Publicado: (2016)

Haplotype architecture of the Alzheimer's risk in the APOE region via co‐skewness
por: Kulminski, Alexander M., et al.
Publicado: (2020)

Exome-Wide Association Study Identified Clusters of Pleiotropic Genetic Associations with Alzheimer’s Disease and Thirteen Cardiovascular Traits
por: Loika, Yury, et al.
Publicado: (2023)

Associations of the APOE ε2 and ε4 alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer’s disease biomarkers
por: Kulminski, Alexander M., et al.
Publicado: (2022)

Pleiotropy of Alzheimer’s Disease and Educational Attainment: Insights from the Summary Statistics
por: Loika, Yury, et al.
Publicado: (2021)

Pleiotropy of Alzheimer’s Disease and Educational Attainment: Insights from the Summary Statistics
por: Loika, Yury, et al.
Publicado: (2021)

Pleiotropic predisposition to Alzheimer’s disease and educational attainment: insights from the summary statistics analysis
por: Kulminski, Alexander M., et al.
Publicado: (2021)

Genetic and regulatory architecture of Alzheimer's disease in the APOE region
por: Kulminski, Alexander M., et al.
Publicado: (2020)

Strong impact of natural-selection–free heterogeneity in genetics of age-related phenotypes
por: Kulminski, Alexander M., et al.
Publicado: (2018)

Apolipoprotein E region molecular signatures of Alzheimer's disease
por: Kulminski, Alexander M., et al.
Publicado: (2018)

Pleiotropic Meta-Analysis of Age-Related Phenotypes Addressing Evolutionary Uncertainty in Their Molecular Mechanisms
por: Kulminski, Alexander M., et al.
Publicado: (2019)

Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart‐related traits
por: Kulminski, Alexander M., et al.
Publicado: (2016)

Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies
por: Kulminski, Alexander M., et al.
Publicado: (2015)

An Approach to Identify New Pleiotropic Genetic Loci From Publicly Available Univariate GWAS Results
por: Loika, Yury, et al.
Publicado: (2020)

APOE ɛ4 allele and TOMM40‐APOC1 variants jointly contribute to survival to older ages
por: Kulminski, Alexander M., et al.
Publicado: (2022)

Independent associations of TOMM40 and APOE variants with body mass index
por: Kulminski, Alexander M., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_i7bvlubnqjkau8qeo011n15b7e