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DYNAMICS OF HUMAN MUCOSAL-ASSOCIATED INVARIANT T CELL REPERTOIRES ACROSS THE HUMAN LIFE SPAN
Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes and are important for immune responses against bacterial and viral infections. While MAIT cells are known to undergo marked numerical changes with age in humans, our understanding of how these cells alter during these different...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6845739/ http://dx.doi.org/10.1093/geroni/igz038.2826 |
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author | Loh, Liyen Lappas, Martha Crowe, Jane Thomas, Paul G Eckle, Sidonia Godfrey, Dale I Kedzierska, Katherine Crawford, Jeremy C |
author_facet | Loh, Liyen Lappas, Martha Crowe, Jane Thomas, Paul G Eckle, Sidonia Godfrey, Dale I Kedzierska, Katherine Crawford, Jeremy C |
author_sort | Loh, Liyen |
collection | PubMed |
description | Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes and are important for immune responses against bacterial and viral infections. While MAIT cells are known to undergo marked numerical changes with age in humans, our understanding of how these cells alter during these different phases across the human lifespan is largely unknown. Here we investigated MAIT cells from umbilical cord, children, young-adults and elderly. Functional analyses across 18-90 y/o adults showed that their MR1-dependent polyfunctionality was robust throughout old age. Strikingly, elderly MAIT cells displayed upregulated basal inflammatory cytokines, which were reduced to the level of young-adult MAIT cells in the absence of the aged environment. T cell receptor αβ analyses of MAIT cells across the human lifespan showed narrowing with age and large clonal TCRαβ expansions in elderly. These data suggest that MAIT cells in the elderly display remarkable plasticity, highlighting MAIT cells as key players in aged immune responses. |
format | Online Article Text |
id | pubmed-6845739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-68457392019-11-18 DYNAMICS OF HUMAN MUCOSAL-ASSOCIATED INVARIANT T CELL REPERTOIRES ACROSS THE HUMAN LIFE SPAN Loh, Liyen Lappas, Martha Crowe, Jane Thomas, Paul G Eckle, Sidonia Godfrey, Dale I Kedzierska, Katherine Crawford, Jeremy C Innov Aging Session 3540 (Symposium) Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes and are important for immune responses against bacterial and viral infections. While MAIT cells are known to undergo marked numerical changes with age in humans, our understanding of how these cells alter during these different phases across the human lifespan is largely unknown. Here we investigated MAIT cells from umbilical cord, children, young-adults and elderly. Functional analyses across 18-90 y/o adults showed that their MR1-dependent polyfunctionality was robust throughout old age. Strikingly, elderly MAIT cells displayed upregulated basal inflammatory cytokines, which were reduced to the level of young-adult MAIT cells in the absence of the aged environment. T cell receptor αβ analyses of MAIT cells across the human lifespan showed narrowing with age and large clonal TCRαβ expansions in elderly. These data suggest that MAIT cells in the elderly display remarkable plasticity, highlighting MAIT cells as key players in aged immune responses. Oxford University Press 2019-11-08 /pmc/articles/PMC6845739/ http://dx.doi.org/10.1093/geroni/igz038.2826 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Session 3540 (Symposium) Loh, Liyen Lappas, Martha Crowe, Jane Thomas, Paul G Eckle, Sidonia Godfrey, Dale I Kedzierska, Katherine Crawford, Jeremy C DYNAMICS OF HUMAN MUCOSAL-ASSOCIATED INVARIANT T CELL REPERTOIRES ACROSS THE HUMAN LIFE SPAN |
title | DYNAMICS OF HUMAN MUCOSAL-ASSOCIATED INVARIANT T CELL REPERTOIRES ACROSS THE HUMAN LIFE SPAN |
title_full | DYNAMICS OF HUMAN MUCOSAL-ASSOCIATED INVARIANT T CELL REPERTOIRES ACROSS THE HUMAN LIFE SPAN |
title_fullStr | DYNAMICS OF HUMAN MUCOSAL-ASSOCIATED INVARIANT T CELL REPERTOIRES ACROSS THE HUMAN LIFE SPAN |
title_full_unstemmed | DYNAMICS OF HUMAN MUCOSAL-ASSOCIATED INVARIANT T CELL REPERTOIRES ACROSS THE HUMAN LIFE SPAN |
title_short | DYNAMICS OF HUMAN MUCOSAL-ASSOCIATED INVARIANT T CELL REPERTOIRES ACROSS THE HUMAN LIFE SPAN |
title_sort | dynamics of human mucosal-associated invariant t cell repertoires across the human life span |
topic | Session 3540 (Symposium) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6845739/ http://dx.doi.org/10.1093/geroni/igz038.2826 |
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