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INCREASED LIFESPAN THROUGH ALTERED GCN4 / ATF-5 IN S. CEREVISIAE AND C. ELEGANS

In a whole-genome screen for deletions that increase lifespan in S. cerevisiae, we identified increased Gcn4 signaling as a mediator of increased lifespan. Gcn4 is a nutrient-responsive transcription factor whose entire pathway is functionally conserved from yeast through humans. Accumulation of unc...

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Detalles Bibliográficos
Autores principales:	McCormick, Mark, Robbins, Christine, Heath, Olivia, Westenskow, Marissa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Session 3195 (Symposium)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6845789/ http://dx.doi.org/10.1093/geroni/igz038.2295

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