Cargando…

SEX-DIMORPHISM IN THE GENOMIC REGULATION OF AGING

The current cohort of human supercentenarians reveals a surprising predictor for achieving such an exceptional longevity: being female. Indeed, out of 34 living supercentenarians, 33 are women. We obtained samples from 4 and 20 months old female and male mice. Our data indicates that cytokine levels...

Descripción completa

Detalles Bibliográficos
Autores principales: Benayoun, Bérénice A, Lu, Ryan A, Sampathkumar, Nirmal K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846027/
http://dx.doi.org/10.1093/geroni/igz038.2825
_version_ 1783468797441605632
author Benayoun, Bérénice A
Lu, Ryan A
Sampathkumar, Nirmal K
author_facet Benayoun, Bérénice A
Lu, Ryan A
Sampathkumar, Nirmal K
author_sort Benayoun, Bérénice A
collection PubMed
description The current cohort of human supercentenarians reveals a surprising predictor for achieving such an exceptional longevity: being female. Indeed, out of 34 living supercentenarians, 33 are women. We obtained samples from 4 and 20 months old female and male mice. Our data indicates that cytokine levels are differentially regulated with age in males vs. females, with pro-inflammatory cytokines specifically upregulated in the serum of old males, but not females. Because of the central role of macrophages in inflammation and their infiltration in tissues with age, we have generated RNA-seq from purified macrophages of aging animals. Female macrophages displayed ~7-20-fold more transcriptional remodeling with aging than males. Pathways specifically downregulated in females with aging included lysosome, inflammation and phagolysosome. Consistently, our data shows that aged female, but not male macrophages, display decreased phagocytic efficiency. Our results support the notion that there are differences in aging trajectories in female vs. male mice.
format Online
Article
Text
id pubmed-6846027
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-68460272019-11-18 SEX-DIMORPHISM IN THE GENOMIC REGULATION OF AGING Benayoun, Bérénice A Lu, Ryan A Sampathkumar, Nirmal K Innov Aging Session 3540 (Symposium) The current cohort of human supercentenarians reveals a surprising predictor for achieving such an exceptional longevity: being female. Indeed, out of 34 living supercentenarians, 33 are women. We obtained samples from 4 and 20 months old female and male mice. Our data indicates that cytokine levels are differentially regulated with age in males vs. females, with pro-inflammatory cytokines specifically upregulated in the serum of old males, but not females. Because of the central role of macrophages in inflammation and their infiltration in tissues with age, we have generated RNA-seq from purified macrophages of aging animals. Female macrophages displayed ~7-20-fold more transcriptional remodeling with aging than males. Pathways specifically downregulated in females with aging included lysosome, inflammation and phagolysosome. Consistently, our data shows that aged female, but not male macrophages, display decreased phagocytic efficiency. Our results support the notion that there are differences in aging trajectories in female vs. male mice. Oxford University Press 2019-11-08 /pmc/articles/PMC6846027/ http://dx.doi.org/10.1093/geroni/igz038.2825 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Session 3540 (Symposium)
Benayoun, Bérénice A
Lu, Ryan A
Sampathkumar, Nirmal K
SEX-DIMORPHISM IN THE GENOMIC REGULATION OF AGING
title SEX-DIMORPHISM IN THE GENOMIC REGULATION OF AGING
title_full SEX-DIMORPHISM IN THE GENOMIC REGULATION OF AGING
title_fullStr SEX-DIMORPHISM IN THE GENOMIC REGULATION OF AGING
title_full_unstemmed SEX-DIMORPHISM IN THE GENOMIC REGULATION OF AGING
title_short SEX-DIMORPHISM IN THE GENOMIC REGULATION OF AGING
title_sort sex-dimorphism in the genomic regulation of aging
topic Session 3540 (Symposium)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846027/
http://dx.doi.org/10.1093/geroni/igz038.2825
work_keys_str_mv AT benayounberenicea sexdimorphisminthegenomicregulationofaging
AT luryana sexdimorphisminthegenomicregulationofaging
AT sampathkumarnirmalk sexdimorphisminthegenomicregulationofaging