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HEAVY ALCOHOL CONSUMPTION IN MIDLIFE IS ASSOCIATED WITH ACCELERATED BRAIN AGING SIX YEARS LATER
Excessive alcohol consumption is associated with cognitive decline, exacerbated brain atrophy, and dementia in older adults, but associations with midlife brain health are less well understood. We hypothesized that heavy drinkers would have older-looking brains in late midlife. We examined alcohol c...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846072/ http://dx.doi.org/10.1093/geroni/igz038.3324 |
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author | Slayday, Riki E Franz, Carol E Hatton, Sean N McEvoy, Linda K Lyons, Michael J Kremen, William S |
author_facet | Slayday, Riki E Franz, Carol E Hatton, Sean N McEvoy, Linda K Lyons, Michael J Kremen, William S |
author_sort | Slayday, Riki E |
collection | PubMed |
description | Excessive alcohol consumption is associated with cognitive decline, exacerbated brain atrophy, and dementia in older adults, but associations with midlife brain health are less well understood. We hypothesized that heavy drinkers would have older-looking brains in late midlife. We examined alcohol consumption at mean age 56 (range 51-59) in 364 men from the Vietnam Era Twin Study of Aging (VETSA) and their predicted brain age at mean age 62 (range 56-67). We created five midlife alcohol consumption groups based on drinks consumed over the past two weeks: never, former, light (1-14), moderate (15-28), and heavy (>28). Participants underwent structural magnetic resonance imaging at mean age 62. Predicted brain age was measured using the Brain-Age Regression Analysis and Computation Utility software (BARACUS). Models adjusted for age, scanner, race/ethnicity, SES, smoking, health, depressive symptoms, alcohol dependence, general cognitive ability at age 20, and non-independence of twins within pairs. Heavy drinkers had a significantly older predicted than chronological brain age (M= 5.93, SE= 0.88) compared to each of the other four groups (p’s < 0.05). There were no significant differences among the never (M= 2.88, SE= 0.98), former (M= 2.76, SE= 0.74), light (M= 3.00, SE= 0.94), or moderate (M= 5.93, SE= 0.88) consumption groups. Heavy alcohol consumption at age 56 was associated with an approximately 3-year greater predicted brain age difference at age 62. There was no evidence of protective effects of light/moderate drinking over non-drinking. The neurotoxic effects of excessive alcohol may exacerbate brain aging in late midlife. |
format | Online Article Text |
id | pubmed-6846072 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-68460722019-11-18 HEAVY ALCOHOL CONSUMPTION IN MIDLIFE IS ASSOCIATED WITH ACCELERATED BRAIN AGING SIX YEARS LATER Slayday, Riki E Franz, Carol E Hatton, Sean N McEvoy, Linda K Lyons, Michael J Kremen, William S Innov Aging Session Lb2570 (Late Breaking Poster) Excessive alcohol consumption is associated with cognitive decline, exacerbated brain atrophy, and dementia in older adults, but associations with midlife brain health are less well understood. We hypothesized that heavy drinkers would have older-looking brains in late midlife. We examined alcohol consumption at mean age 56 (range 51-59) in 364 men from the Vietnam Era Twin Study of Aging (VETSA) and their predicted brain age at mean age 62 (range 56-67). We created five midlife alcohol consumption groups based on drinks consumed over the past two weeks: never, former, light (1-14), moderate (15-28), and heavy (>28). Participants underwent structural magnetic resonance imaging at mean age 62. Predicted brain age was measured using the Brain-Age Regression Analysis and Computation Utility software (BARACUS). Models adjusted for age, scanner, race/ethnicity, SES, smoking, health, depressive symptoms, alcohol dependence, general cognitive ability at age 20, and non-independence of twins within pairs. Heavy drinkers had a significantly older predicted than chronological brain age (M= 5.93, SE= 0.88) compared to each of the other four groups (p’s < 0.05). There were no significant differences among the never (M= 2.88, SE= 0.98), former (M= 2.76, SE= 0.74), light (M= 3.00, SE= 0.94), or moderate (M= 5.93, SE= 0.88) consumption groups. Heavy alcohol consumption at age 56 was associated with an approximately 3-year greater predicted brain age difference at age 62. There was no evidence of protective effects of light/moderate drinking over non-drinking. The neurotoxic effects of excessive alcohol may exacerbate brain aging in late midlife. Oxford University Press 2019-11-08 /pmc/articles/PMC6846072/ http://dx.doi.org/10.1093/geroni/igz038.3324 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Session Lb2570 (Late Breaking Poster) Slayday, Riki E Franz, Carol E Hatton, Sean N McEvoy, Linda K Lyons, Michael J Kremen, William S HEAVY ALCOHOL CONSUMPTION IN MIDLIFE IS ASSOCIATED WITH ACCELERATED BRAIN AGING SIX YEARS LATER |
title | HEAVY ALCOHOL CONSUMPTION IN MIDLIFE IS ASSOCIATED WITH ACCELERATED BRAIN AGING SIX YEARS LATER |
title_full | HEAVY ALCOHOL CONSUMPTION IN MIDLIFE IS ASSOCIATED WITH ACCELERATED BRAIN AGING SIX YEARS LATER |
title_fullStr | HEAVY ALCOHOL CONSUMPTION IN MIDLIFE IS ASSOCIATED WITH ACCELERATED BRAIN AGING SIX YEARS LATER |
title_full_unstemmed | HEAVY ALCOHOL CONSUMPTION IN MIDLIFE IS ASSOCIATED WITH ACCELERATED BRAIN AGING SIX YEARS LATER |
title_short | HEAVY ALCOHOL CONSUMPTION IN MIDLIFE IS ASSOCIATED WITH ACCELERATED BRAIN AGING SIX YEARS LATER |
title_sort | heavy alcohol consumption in midlife is associated with accelerated brain aging six years later |
topic | Session Lb2570 (Late Breaking Poster) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846072/ http://dx.doi.org/10.1093/geroni/igz038.3324 |
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