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LIFETIME EXERCISE ATTENUATES AGE- AND WESTERN DIET-RELATED DECLINES IN PHYSICAL FUNCTION IN MICE
Aging is associated with progressive declines in physical function. However, it is unknown if consumption of a western-style diet (WD; high-fat and sucrose, low fiber), compared with a non-WD (healthy diet), accelerates declines in physical function over the adult lifespan, and whether regular volun...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846338/ http://dx.doi.org/10.1093/geroni/igz038.391 |
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author | Clayton, Zachary S Gioscia-Ryan, Rachel A Justice, Jamie N Lubieniecki, Kara Rossman, Matthew Zigler, Melanie Seals, Douglas |
author_facet | Clayton, Zachary S Gioscia-Ryan, Rachel A Justice, Jamie N Lubieniecki, Kara Rossman, Matthew Zigler, Melanie Seals, Douglas |
author_sort | Clayton, Zachary S |
collection | PubMed |
description | Aging is associated with progressive declines in physical function. However, it is unknown if consumption of a western-style diet (WD; high-fat and sucrose, low fiber), compared with a non-WD (healthy diet), accelerates declines in physical function over the adult lifespan, and whether regular voluntary exercise attenuates age- and WD-associated declines in function. To determine this, we studied 4 cohorts of male C57BL/6 mice that consumed either normal chow [NC] or WD with or without access to voluntary running [VR] wheels beginning at 3 mo of age and assessed strength (grip strength normalized to body mass) and endurance (rota-rod distance) every 3 mo throughout life. WD decreased average lifespan by 30% (WD: 18.6±0.5 vs. NC: 26.7±0.8 mo); therefore, function was compared from 3-18 mo of age in all groups. Age-related declines (% change over 3-18 mo) in physical function were accelerated by WD (strength: WD -61.2±10.1%, NC -43.2±10.2%; endurance: WD -97.4±5.1%, NC -65.1±6.3%; all p<0.05 WD vs. NC). VR attenuated declines in physical function within the same diet group (strength: WDVR -34.7±5.1%, NCVR -18.6±5.2%; endurance: WDVR -48.5±5.2%, NCVR -41.4±4.7%; all p<0.05 versus same diet non-VR group). These unique data obtained from a lifelong study of aging in mice, indicate that: 1) consuming a WD reduces lifespan and accelerates age-related declines in physical function by 40-50% vs. a non-WD; regular voluntary exercise (wheel running) prevents this effect of WD on physical function; and 2) regular voluntary exercise also attenuates the age-associated decline in physical function by ~60-130% when consuming a healthy diet. |
format | Online Article Text |
id | pubmed-6846338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-68463382019-11-18 LIFETIME EXERCISE ATTENUATES AGE- AND WESTERN DIET-RELATED DECLINES IN PHYSICAL FUNCTION IN MICE Clayton, Zachary S Gioscia-Ryan, Rachel A Justice, Jamie N Lubieniecki, Kara Rossman, Matthew Zigler, Melanie Seals, Douglas Innov Aging Session 835 (Poster) Aging is associated with progressive declines in physical function. However, it is unknown if consumption of a western-style diet (WD; high-fat and sucrose, low fiber), compared with a non-WD (healthy diet), accelerates declines in physical function over the adult lifespan, and whether regular voluntary exercise attenuates age- and WD-associated declines in function. To determine this, we studied 4 cohorts of male C57BL/6 mice that consumed either normal chow [NC] or WD with or without access to voluntary running [VR] wheels beginning at 3 mo of age and assessed strength (grip strength normalized to body mass) and endurance (rota-rod distance) every 3 mo throughout life. WD decreased average lifespan by 30% (WD: 18.6±0.5 vs. NC: 26.7±0.8 mo); therefore, function was compared from 3-18 mo of age in all groups. Age-related declines (% change over 3-18 mo) in physical function were accelerated by WD (strength: WD -61.2±10.1%, NC -43.2±10.2%; endurance: WD -97.4±5.1%, NC -65.1±6.3%; all p<0.05 WD vs. NC). VR attenuated declines in physical function within the same diet group (strength: WDVR -34.7±5.1%, NCVR -18.6±5.2%; endurance: WDVR -48.5±5.2%, NCVR -41.4±4.7%; all p<0.05 versus same diet non-VR group). These unique data obtained from a lifelong study of aging in mice, indicate that: 1) consuming a WD reduces lifespan and accelerates age-related declines in physical function by 40-50% vs. a non-WD; regular voluntary exercise (wheel running) prevents this effect of WD on physical function; and 2) regular voluntary exercise also attenuates the age-associated decline in physical function by ~60-130% when consuming a healthy diet. Oxford University Press 2019-11-08 /pmc/articles/PMC6846338/ http://dx.doi.org/10.1093/geroni/igz038.391 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Session 835 (Poster) Clayton, Zachary S Gioscia-Ryan, Rachel A Justice, Jamie N Lubieniecki, Kara Rossman, Matthew Zigler, Melanie Seals, Douglas LIFETIME EXERCISE ATTENUATES AGE- AND WESTERN DIET-RELATED DECLINES IN PHYSICAL FUNCTION IN MICE |
title | LIFETIME EXERCISE ATTENUATES AGE- AND WESTERN DIET-RELATED DECLINES IN PHYSICAL FUNCTION IN MICE |
title_full | LIFETIME EXERCISE ATTENUATES AGE- AND WESTERN DIET-RELATED DECLINES IN PHYSICAL FUNCTION IN MICE |
title_fullStr | LIFETIME EXERCISE ATTENUATES AGE- AND WESTERN DIET-RELATED DECLINES IN PHYSICAL FUNCTION IN MICE |
title_full_unstemmed | LIFETIME EXERCISE ATTENUATES AGE- AND WESTERN DIET-RELATED DECLINES IN PHYSICAL FUNCTION IN MICE |
title_short | LIFETIME EXERCISE ATTENUATES AGE- AND WESTERN DIET-RELATED DECLINES IN PHYSICAL FUNCTION IN MICE |
title_sort | lifetime exercise attenuates age- and western diet-related declines in physical function in mice |
topic | Session 835 (Poster) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846338/ http://dx.doi.org/10.1093/geroni/igz038.391 |
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