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THE ASSOCIATION BETWEEN VITAMIN K STATUS AND CARDIOVASCULAR DISEASE IN OLDER ADULTS

A role for vitamin K in cardiovascular disease (CVD) has been proposed because vitamin K-dependent proteins are present in vascular tissue. We evaluated the association between vitamin K status and incident CVD and mortality in older adults from the Health, Aging, and Body Composition Study (Health...

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Autores principales: Shea, M Kyla, Weiner, Daniel, Matuszek, Gergory, Booth, Sarah L, Kritchevsky, Stephen, Cushman, Mary, Barger, Kathryn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846516/
http://dx.doi.org/10.1093/geroni/igz038.2393
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author Shea, M Kyla
Weiner, Daniel
Matuszek, Gergory
Booth, Sarah L
Kritchevsky, Stephen
Cushman, Mary
Barger, Kathryn
author_facet Shea, M Kyla
Weiner, Daniel
Matuszek, Gergory
Booth, Sarah L
Kritchevsky, Stephen
Cushman, Mary
Barger, Kathryn
author_sort Shea, M Kyla
collection PubMed
description A role for vitamin K in cardiovascular disease (CVD) has been proposed because vitamin K-dependent proteins are present in vascular tissue. We evaluated the association between vitamin K status and incident CVD and mortality in older adults from the Health, Aging, and Body Composition Study (Health ABC), and conducted a replication analysis using the Multi-ethnic Study of Atherosclerosis (MESA). In both cohorts circulating phylloquinone (vitamin K1), measured from baseline fasting blood samples, was categorized as ≤0.5nM, >0.5-≤1.0nM, and >1.0nM. Multivariable Cox proportional hazards models assessed the association between circulating phylloquinone and risk of a composite of CVD and mortality. In Health ABC (n=1246, mean age 74 years, 57% female, 58% Caucasian), over a median 11.5 follow-up years, participants with ≤0.5 nM plasma phylloquinone (n=351) had a 27% higher risk for CVD and mortality compared to those with >1.0nM (n=457) [adjusted hazard ratio (95% confidence interval) (HR(95%CI)): 1.27(1.06-1.52)]. However, the risk for CVD and mortality did not differ between those with >0.5-≤1.0nM (n=438) and with >1.0nM plasma phylloquinone [HR(95%CI): 1.03(0.87-1.52)]. Serum phylloquinone was similarly associated with CVD and mortality in MESA, over a median 12.1 follow-up years (n=764, mean age 62 years, 54% female, 35% Caucasian) [HR(95%CI), compared to those with >1.0nM (n=368): <0.5nM (n=253): 1.54(1.03-2.32); 0.5-≤1.0nM (n=153): 1.23(0.76, 1.98)]. Lower circulating phylloquinone was associated with a higher CVD and mortality risk in two independent cohorts. Additional studies are needed to corroborate our findings and clarify if certain segments of the population can derive cardiovascular benefit from improving vitamin K status.
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spelling pubmed-68465162019-11-18 THE ASSOCIATION BETWEEN VITAMIN K STATUS AND CARDIOVASCULAR DISEASE IN OLDER ADULTS Shea, M Kyla Weiner, Daniel Matuszek, Gergory Booth, Sarah L Kritchevsky, Stephen Cushman, Mary Barger, Kathryn Innov Aging Session 3280 (Poster) A role for vitamin K in cardiovascular disease (CVD) has been proposed because vitamin K-dependent proteins are present in vascular tissue. We evaluated the association between vitamin K status and incident CVD and mortality in older adults from the Health, Aging, and Body Composition Study (Health ABC), and conducted a replication analysis using the Multi-ethnic Study of Atherosclerosis (MESA). In both cohorts circulating phylloquinone (vitamin K1), measured from baseline fasting blood samples, was categorized as ≤0.5nM, >0.5-≤1.0nM, and >1.0nM. Multivariable Cox proportional hazards models assessed the association between circulating phylloquinone and risk of a composite of CVD and mortality. In Health ABC (n=1246, mean age 74 years, 57% female, 58% Caucasian), over a median 11.5 follow-up years, participants with ≤0.5 nM plasma phylloquinone (n=351) had a 27% higher risk for CVD and mortality compared to those with >1.0nM (n=457) [adjusted hazard ratio (95% confidence interval) (HR(95%CI)): 1.27(1.06-1.52)]. However, the risk for CVD and mortality did not differ between those with >0.5-≤1.0nM (n=438) and with >1.0nM plasma phylloquinone [HR(95%CI): 1.03(0.87-1.52)]. Serum phylloquinone was similarly associated with CVD and mortality in MESA, over a median 12.1 follow-up years (n=764, mean age 62 years, 54% female, 35% Caucasian) [HR(95%CI), compared to those with >1.0nM (n=368): <0.5nM (n=253): 1.54(1.03-2.32); 0.5-≤1.0nM (n=153): 1.23(0.76, 1.98)]. Lower circulating phylloquinone was associated with a higher CVD and mortality risk in two independent cohorts. Additional studies are needed to corroborate our findings and clarify if certain segments of the population can derive cardiovascular benefit from improving vitamin K status. Oxford University Press 2019-11-08 /pmc/articles/PMC6846516/ http://dx.doi.org/10.1093/geroni/igz038.2393 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Session 3280 (Poster)
Shea, M Kyla
Weiner, Daniel
Matuszek, Gergory
Booth, Sarah L
Kritchevsky, Stephen
Cushman, Mary
Barger, Kathryn
THE ASSOCIATION BETWEEN VITAMIN K STATUS AND CARDIOVASCULAR DISEASE IN OLDER ADULTS
title THE ASSOCIATION BETWEEN VITAMIN K STATUS AND CARDIOVASCULAR DISEASE IN OLDER ADULTS
title_full THE ASSOCIATION BETWEEN VITAMIN K STATUS AND CARDIOVASCULAR DISEASE IN OLDER ADULTS
title_fullStr THE ASSOCIATION BETWEEN VITAMIN K STATUS AND CARDIOVASCULAR DISEASE IN OLDER ADULTS
title_full_unstemmed THE ASSOCIATION BETWEEN VITAMIN K STATUS AND CARDIOVASCULAR DISEASE IN OLDER ADULTS
title_short THE ASSOCIATION BETWEEN VITAMIN K STATUS AND CARDIOVASCULAR DISEASE IN OLDER ADULTS
title_sort association between vitamin k status and cardiovascular disease in older adults
topic Session 3280 (Poster)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846516/
http://dx.doi.org/10.1093/geroni/igz038.2393
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