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THE HEALTHY AGING INDEX AND ITS ASSOCIATION WITH MORTALITY IN OLDER MEXICAN AND EUROPEAN AMERICANS

Mexican Americans (MA) have higher morbidity compared to European Americans (EA); however, the mortality rate remains lower (Hispanic Paradox). The Healthy Aging Index (HAI) captures clinical and subclinical morbidity in older adults and is useful in examining ethnic differences in mortality for a g...

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Autores principales: Ganapathy, Vinutha, Jacob, Mini E, Short, Meghan I, Gonzales, Mitzi M, Barrera, Claudia Satizabal, Seshadri, Sudha, Wang, Chen-pin, Hazuda, Helen P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846529/
http://dx.doi.org/10.1093/geroni/igz038.3481
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author Ganapathy, Vinutha
Jacob, Mini E
Short, Meghan I
Gonzales, Mitzi M
Barrera, Claudia Satizabal
Seshadri, Sudha
Wang, Chen-pin
Hazuda, Helen P
author_facet Ganapathy, Vinutha
Jacob, Mini E
Short, Meghan I
Gonzales, Mitzi M
Barrera, Claudia Satizabal
Seshadri, Sudha
Wang, Chen-pin
Hazuda, Helen P
author_sort Ganapathy, Vinutha
collection PubMed
description Mexican Americans (MA) have higher morbidity compared to European Americans (EA); however, the mortality rate remains lower (Hispanic Paradox). The Healthy Aging Index (HAI) captures clinical and subclinical morbidity in older adults and is useful in examining ethnic differences in mortality for a given disease burden. We assessed the association between baseline HAI and all-cause mortality over 12 years of follow-up among older MAs (n=394) and EAs (n=355) in the San Antonio Longitudinal Study of Aging (SALSA) and examined differences between ethnic groups. HAI incorporates non-invasive measures (systolic blood pressure, forced vital capacity, creatinine, fasting plasma glucose (FPG), Mini-Mental State Exam). Missing baseline data for HAI components and covariates were imputed using multiple imputations. Proteinuria was used instead of creatinine due to non-availability. Scores of 0, 1, 2 were given from lowest to highest tertile HAI categories; diagnosis of diabetes, hypertension, and renal failure were included in the highest tertiles. Cox proportional hazards models estimated the association between HAI and mortality, adjusting for confounders. After adjusting for age, gender, education, income, BMI, smoking and ethnicity, HAI was independently associated with mortality (HR 1.25 (1.16-1.35), p-value <0.0001). We found no interaction effect between HAI and ethnicity on mortality ((p-value for interaction = 0.78). In the SALSA sample, HAI is a predictor of mortality after adjusting for confounders in both MAs and EAs. The absence of a significant HAI*ethnicity interaction effect further demonstrated that HAI works equally well as a predictor of mortality in both MAs and EAs.
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spelling pubmed-68465292019-11-18 THE HEALTHY AGING INDEX AND ITS ASSOCIATION WITH MORTALITY IN OLDER MEXICAN AND EUROPEAN AMERICANS Ganapathy, Vinutha Jacob, Mini E Short, Meghan I Gonzales, Mitzi M Barrera, Claudia Satizabal Seshadri, Sudha Wang, Chen-pin Hazuda, Helen P Innov Aging Session Lb3620 (Late Breaking Poster) Mexican Americans (MA) have higher morbidity compared to European Americans (EA); however, the mortality rate remains lower (Hispanic Paradox). The Healthy Aging Index (HAI) captures clinical and subclinical morbidity in older adults and is useful in examining ethnic differences in mortality for a given disease burden. We assessed the association between baseline HAI and all-cause mortality over 12 years of follow-up among older MAs (n=394) and EAs (n=355) in the San Antonio Longitudinal Study of Aging (SALSA) and examined differences between ethnic groups. HAI incorporates non-invasive measures (systolic blood pressure, forced vital capacity, creatinine, fasting plasma glucose (FPG), Mini-Mental State Exam). Missing baseline data for HAI components and covariates were imputed using multiple imputations. Proteinuria was used instead of creatinine due to non-availability. Scores of 0, 1, 2 were given from lowest to highest tertile HAI categories; diagnosis of diabetes, hypertension, and renal failure were included in the highest tertiles. Cox proportional hazards models estimated the association between HAI and mortality, adjusting for confounders. After adjusting for age, gender, education, income, BMI, smoking and ethnicity, HAI was independently associated with mortality (HR 1.25 (1.16-1.35), p-value <0.0001). We found no interaction effect between HAI and ethnicity on mortality ((p-value for interaction = 0.78). In the SALSA sample, HAI is a predictor of mortality after adjusting for confounders in both MAs and EAs. The absence of a significant HAI*ethnicity interaction effect further demonstrated that HAI works equally well as a predictor of mortality in both MAs and EAs. Oxford University Press 2019-11-08 /pmc/articles/PMC6846529/ http://dx.doi.org/10.1093/geroni/igz038.3481 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Session Lb3620 (Late Breaking Poster)
Ganapathy, Vinutha
Jacob, Mini E
Short, Meghan I
Gonzales, Mitzi M
Barrera, Claudia Satizabal
Seshadri, Sudha
Wang, Chen-pin
Hazuda, Helen P
THE HEALTHY AGING INDEX AND ITS ASSOCIATION WITH MORTALITY IN OLDER MEXICAN AND EUROPEAN AMERICANS
title THE HEALTHY AGING INDEX AND ITS ASSOCIATION WITH MORTALITY IN OLDER MEXICAN AND EUROPEAN AMERICANS
title_full THE HEALTHY AGING INDEX AND ITS ASSOCIATION WITH MORTALITY IN OLDER MEXICAN AND EUROPEAN AMERICANS
title_fullStr THE HEALTHY AGING INDEX AND ITS ASSOCIATION WITH MORTALITY IN OLDER MEXICAN AND EUROPEAN AMERICANS
title_full_unstemmed THE HEALTHY AGING INDEX AND ITS ASSOCIATION WITH MORTALITY IN OLDER MEXICAN AND EUROPEAN AMERICANS
title_short THE HEALTHY AGING INDEX AND ITS ASSOCIATION WITH MORTALITY IN OLDER MEXICAN AND EUROPEAN AMERICANS
title_sort healthy aging index and its association with mortality in older mexican and european americans
topic Session Lb3620 (Late Breaking Poster)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846529/
http://dx.doi.org/10.1093/geroni/igz038.3481
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