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UP-REGULATION OF LONG NON-CODING RNA MORBID ATTENUATES SENESCENCE
Aging is the inevitable, irreversible decline in function on the cellular and organ level leading to increased incidence of the most frequent diseases such as cancer and cardiovascular disease, that occurs over time. whereas the molecular mechanisms of senescence remain largely unknown. Here we iden...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846815/ http://dx.doi.org/10.1093/geroni/igz038.344 |
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author | Kuai, Zheng Chen, Meiting yu, yang Yang, Fan Zhang, chunxiang |
author_facet | Kuai, Zheng Chen, Meiting yu, yang Yang, Fan Zhang, chunxiang |
author_sort | Kuai, Zheng |
collection | PubMed |
description | Aging is the inevitable, irreversible decline in function on the cellular and organ level leading to increased incidence of the most frequent diseases such as cancer and cardiovascular disease, that occurs over time. whereas the molecular mechanisms of senescence remain largely unknown. Here we identified that a novel long noncoding RNA, Morrbid was significantly decreased in different organs of aged mice, such as heart, liver, spleen, lung, kidney and brain. Interestingly, the telomeres length of Morrbid KO mice were significantly shorted than the WT mice at the same age. We also found that Morrbid was steeply decreased in a natural mouse cardiac myocyte senescence model. The senescence of mouse cardiac myocytes was effectively attenuated by Morrbid over-expression shown by the decreased β-galactosidase staining, increased telomere activity, decreased production of ROS and decreased cell apoptosis, but was enhanced by Morrbid knockdown. The results suggest that Morrbid is a critical regulator in senescence and could be used as a novel diagnostic biomarker for it, and a new therapeutic target for diverse diseases. |
format | Online Article Text |
id | pubmed-6846815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-68468152019-11-21 UP-REGULATION OF LONG NON-CODING RNA MORBID ATTENUATES SENESCENCE Kuai, Zheng Chen, Meiting yu, yang Yang, Fan Zhang, chunxiang Innov Aging Session 825 (Poster) Aging is the inevitable, irreversible decline in function on the cellular and organ level leading to increased incidence of the most frequent diseases such as cancer and cardiovascular disease, that occurs over time. whereas the molecular mechanisms of senescence remain largely unknown. Here we identified that a novel long noncoding RNA, Morrbid was significantly decreased in different organs of aged mice, such as heart, liver, spleen, lung, kidney and brain. Interestingly, the telomeres length of Morrbid KO mice were significantly shorted than the WT mice at the same age. We also found that Morrbid was steeply decreased in a natural mouse cardiac myocyte senescence model. The senescence of mouse cardiac myocytes was effectively attenuated by Morrbid over-expression shown by the decreased β-galactosidase staining, increased telomere activity, decreased production of ROS and decreased cell apoptosis, but was enhanced by Morrbid knockdown. The results suggest that Morrbid is a critical regulator in senescence and could be used as a novel diagnostic biomarker for it, and a new therapeutic target for diverse diseases. Oxford University Press 2019-11-08 /pmc/articles/PMC6846815/ http://dx.doi.org/10.1093/geroni/igz038.344 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Session 825 (Poster) Kuai, Zheng Chen, Meiting yu, yang Yang, Fan Zhang, chunxiang UP-REGULATION OF LONG NON-CODING RNA MORBID ATTENUATES SENESCENCE |
title | UP-REGULATION OF LONG NON-CODING RNA MORBID ATTENUATES SENESCENCE |
title_full | UP-REGULATION OF LONG NON-CODING RNA MORBID ATTENUATES SENESCENCE |
title_fullStr | UP-REGULATION OF LONG NON-CODING RNA MORBID ATTENUATES SENESCENCE |
title_full_unstemmed | UP-REGULATION OF LONG NON-CODING RNA MORBID ATTENUATES SENESCENCE |
title_short | UP-REGULATION OF LONG NON-CODING RNA MORBID ATTENUATES SENESCENCE |
title_sort | up-regulation of long non-coding rna morbid attenuates senescence |
topic | Session 825 (Poster) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846815/ http://dx.doi.org/10.1093/geroni/igz038.344 |
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