Quantifying the impact of small molecule ligands on G-quadruplex stability against Bloom helicase

G-quadruplex (GQ) stabilizing small molecule (SM) ligands have been used to stabilize human telomeric GQ (hGQ) to inhibit telomerase activity, or non-telomeric GQs to manipulate gene expression at transcription or translation level. GQs are known to inhibit DNA replication unless destabilized by hel...

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Detalles Bibliográficos
Autores principales: Maleki, Parastoo, Mustafa, Golam, Gyawali, Prabesh, Budhathoki, Jagat B, Ma, Yue, Nagasawa, Kazuo, Balci, Hamza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6847008/
https://www.ncbi.nlm.nih.gov/pubmed/31544934
http://dx.doi.org/10.1093/nar/gkz803

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