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Targeted live-cell nuclear delivery of the DNA ‘light-switching’ Ru(II) complex via ion-pairing with chlorophenolate counter-anions: the critical role of binding stability and lipophilicity of the ion-pairing complexes

We have found recently that nuclear uptake of the cell-impermeable DNA light-switching Ru(II)-polypyridyl cationic complexes such as [Ru(bpy)(2)(dppz)]Cl(2) was remarkably enhanced by pentachlorophenol (PCP), by forming ion-pairing complexes via a passive diffusion mechanism. However, it is not clea...

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Detalles Bibliográficos
Autores principales:	Chao, Xi-Juan, Tang, Miao, Huang, Rong, Huang, Chun-Hua, Shao, Jie, Yan, Zhu-Ying, Zhu, Ben-Zhan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6847114/ https://www.ncbi.nlm.nih.gov/pubmed/31584083 http://dx.doi.org/10.1093/nar/gkz152

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