Corticosteroids for Posttransplant Immune Reconstitution Syndrome in Cryptococcus gattii Meningoencephalitis: Case Report and Literature Review

Cryptococcus gattii represents an emerging fungal pathogen of immunocompromised and immunocompetent hosts in the United States. To our knowledge, this is the first case of posttransplant immune reconstitution syndrome due to C. gattii meningoencephalitis successfully treated with corticosteroids. We...

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Detalles Bibliográficos
Autores principales: Canfield, Gregory S, Henao-Martínez, Andrés F, Franco-Paredes, Carlos, Zhelnin, Kristen, Wilson, Michael L, Shihadeh, Katherine C, Wyles, David, Gardner, Edward M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6847472/
https://www.ncbi.nlm.nih.gov/pubmed/31737740
http://dx.doi.org/10.1093/ofid/ofz460
Descripción
Sumario:Cryptococcus gattii represents an emerging fungal pathogen of immunocompromised and immunocompetent hosts in the United States. To our knowledge, this is the first case of posttransplant immune reconstitution syndrome due to C. gattii meningoencephalitis successfully treated with corticosteroids. We also report successful maintenance phase treatment with isavuconazole, a novel triazole, following fluconazole-induced prolonged QT syndrome.

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