Corticosteroids for Posttransplant Immune Reconstitution Syndrome in Cryptococcus gattii Meningoencephalitis: Case Report and Literature Review

Cryptococcus gattii represents an emerging fungal pathogen of immunocompromised and immunocompetent hosts in the United States. To our knowledge, this is the first case of posttransplant immune reconstitution syndrome due to C. gattii meningoencephalitis successfully treated with corticosteroids. We...

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Autores principales: Canfield, Gregory S, Henao-Martínez, Andrés F, Franco-Paredes, Carlos, Zhelnin, Kristen, Wilson, Michael L, Shihadeh, Katherine C, Wyles, David, Gardner, Edward M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6847472/
https://www.ncbi.nlm.nih.gov/pubmed/31737740
http://dx.doi.org/10.1093/ofid/ofz460
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author Canfield, Gregory S
Henao-Martínez, Andrés F
Franco-Paredes, Carlos
Zhelnin, Kristen
Wilson, Michael L
Shihadeh, Katherine C
Wyles, David
Gardner, Edward M
author_facet Canfield, Gregory S
Henao-Martínez, Andrés F
Franco-Paredes, Carlos
Zhelnin, Kristen
Wilson, Michael L
Shihadeh, Katherine C
Wyles, David
Gardner, Edward M
author_sort Canfield, Gregory S
collection PubMed
description Cryptococcus gattii represents an emerging fungal pathogen of immunocompromised and immunocompetent hosts in the United States. To our knowledge, this is the first case of posttransplant immune reconstitution syndrome due to C. gattii meningoencephalitis successfully treated with corticosteroids. We also report successful maintenance phase treatment with isavuconazole, a novel triazole, following fluconazole-induced prolonged QT syndrome.
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spelling pubmed-68474722019-11-15 Corticosteroids for Posttransplant Immune Reconstitution Syndrome in Cryptococcus gattii Meningoencephalitis: Case Report and Literature Review Canfield, Gregory S Henao-Martínez, Andrés F Franco-Paredes, Carlos Zhelnin, Kristen Wilson, Michael L Shihadeh, Katherine C Wyles, David Gardner, Edward M Open Forum Infect Dis Brief Report Cryptococcus gattii represents an emerging fungal pathogen of immunocompromised and immunocompetent hosts in the United States. To our knowledge, this is the first case of posttransplant immune reconstitution syndrome due to C. gattii meningoencephalitis successfully treated with corticosteroids. We also report successful maintenance phase treatment with isavuconazole, a novel triazole, following fluconazole-induced prolonged QT syndrome. Oxford University Press 2019-10-23 /pmc/articles/PMC6847472/ /pubmed/31737740 http://dx.doi.org/10.1093/ofid/ofz460 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Canfield, Gregory S
Henao-Martínez, Andrés F
Franco-Paredes, Carlos
Zhelnin, Kristen
Wilson, Michael L
Shihadeh, Katherine C
Wyles, David
Gardner, Edward M
Corticosteroids for Posttransplant Immune Reconstitution Syndrome in Cryptococcus gattii Meningoencephalitis: Case Report and Literature Review
title Corticosteroids for Posttransplant Immune Reconstitution Syndrome in Cryptococcus gattii Meningoencephalitis: Case Report and Literature Review
title_full Corticosteroids for Posttransplant Immune Reconstitution Syndrome in Cryptococcus gattii Meningoencephalitis: Case Report and Literature Review
title_fullStr Corticosteroids for Posttransplant Immune Reconstitution Syndrome in Cryptococcus gattii Meningoencephalitis: Case Report and Literature Review
title_full_unstemmed Corticosteroids for Posttransplant Immune Reconstitution Syndrome in Cryptococcus gattii Meningoencephalitis: Case Report and Literature Review
title_short Corticosteroids for Posttransplant Immune Reconstitution Syndrome in Cryptococcus gattii Meningoencephalitis: Case Report and Literature Review
title_sort corticosteroids for posttransplant immune reconstitution syndrome in cryptococcus gattii meningoencephalitis: case report and literature review
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6847472/
https://www.ncbi.nlm.nih.gov/pubmed/31737740
http://dx.doi.org/10.1093/ofid/ofz460
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