Serum Bactericidal Activity Levels Monitor to Guide Intravenous Dalbavancin Chronic Suppressive Therapy of Inoperable Staphylococcal Prosthetic Valve Endocarditis: A Case Report

Here we describe a case of a methicillin-resistant coagulase-negative staphylococci prosthetic valve endocarditis in a patient considered not eligible for valve replacement due to high perioperative mortality risk and who did not tolerate oral antibiotic treatment. Under these circumstances, intrave...

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Detalles Bibliográficos
Autores principales: Spaziante, Martina, Franchi, Cristiana, Taliani, Gloria, D’Avolio, Antonio, Pietropaolo, Valeria, Biliotti, Elisa, Esvan, Rozenn, Venditti, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Id Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6847610/
https://www.ncbi.nlm.nih.gov/pubmed/31737736
http://dx.doi.org/10.1093/ofid/ofz427
Descripción
Sumario:Here we describe a case of a methicillin-resistant coagulase-negative staphylococci prosthetic valve endocarditis in a patient considered not eligible for valve replacement due to high perioperative mortality risk and who did not tolerate oral antibiotic treatment. Under these circumstances, intravenous long-term chronic suppressive antibiotic therapy with dalbavancin, scheduling the doses using the serum bactericidal activity titers, proved to be safe and effective.

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