Serum Bactericidal Activity Levels Monitor to Guide Intravenous Dalbavancin Chronic Suppressive Therapy of Inoperable Staphylococcal Prosthetic Valve Endocarditis: A Case Report

Here we describe a case of a methicillin-resistant coagulase-negative staphylococci prosthetic valve endocarditis in a patient considered not eligible for valve replacement due to high perioperative mortality risk and who did not tolerate oral antibiotic treatment. Under these circumstances, intrave...

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Autores principales: Spaziante, Martina, Franchi, Cristiana, Taliani, Gloria, D’Avolio, Antonio, Pietropaolo, Valeria, Biliotti, Elisa, Esvan, Rozenn, Venditti, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Id Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6847610/
https://www.ncbi.nlm.nih.gov/pubmed/31737736
http://dx.doi.org/10.1093/ofid/ofz427
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author Spaziante, Martina
Franchi, Cristiana
Taliani, Gloria
D’Avolio, Antonio
Pietropaolo, Valeria
Biliotti, Elisa
Esvan, Rozenn
Venditti, Mario
author_facet Spaziante, Martina
Franchi, Cristiana
Taliani, Gloria
D’Avolio, Antonio
Pietropaolo, Valeria
Biliotti, Elisa
Esvan, Rozenn
Venditti, Mario
author_sort Spaziante, Martina
collection PubMed
description Here we describe a case of a methicillin-resistant coagulase-negative staphylococci prosthetic valve endocarditis in a patient considered not eligible for valve replacement due to high perioperative mortality risk and who did not tolerate oral antibiotic treatment. Under these circumstances, intravenous long-term chronic suppressive antibiotic therapy with dalbavancin, scheduling the doses using the serum bactericidal activity titers, proved to be safe and effective.
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spelling pubmed-68476102019-11-15 Serum Bactericidal Activity Levels Monitor to Guide Intravenous Dalbavancin Chronic Suppressive Therapy of Inoperable Staphylococcal Prosthetic Valve Endocarditis: A Case Report Spaziante, Martina Franchi, Cristiana Taliani, Gloria D’Avolio, Antonio Pietropaolo, Valeria Biliotti, Elisa Esvan, Rozenn Venditti, Mario Open Forum Infect Dis Id Case Here we describe a case of a methicillin-resistant coagulase-negative staphylococci prosthetic valve endocarditis in a patient considered not eligible for valve replacement due to high perioperative mortality risk and who did not tolerate oral antibiotic treatment. Under these circumstances, intravenous long-term chronic suppressive antibiotic therapy with dalbavancin, scheduling the doses using the serum bactericidal activity titers, proved to be safe and effective. Oxford University Press 2019-09-30 /pmc/articles/PMC6847610/ /pubmed/31737736 http://dx.doi.org/10.1093/ofid/ofz427 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Id Case
Spaziante, Martina
Franchi, Cristiana
Taliani, Gloria
D’Avolio, Antonio
Pietropaolo, Valeria
Biliotti, Elisa
Esvan, Rozenn
Venditti, Mario
Serum Bactericidal Activity Levels Monitor to Guide Intravenous Dalbavancin Chronic Suppressive Therapy of Inoperable Staphylococcal Prosthetic Valve Endocarditis: A Case Report
title Serum Bactericidal Activity Levels Monitor to Guide Intravenous Dalbavancin Chronic Suppressive Therapy of Inoperable Staphylococcal Prosthetic Valve Endocarditis: A Case Report
title_full Serum Bactericidal Activity Levels Monitor to Guide Intravenous Dalbavancin Chronic Suppressive Therapy of Inoperable Staphylococcal Prosthetic Valve Endocarditis: A Case Report
title_fullStr Serum Bactericidal Activity Levels Monitor to Guide Intravenous Dalbavancin Chronic Suppressive Therapy of Inoperable Staphylococcal Prosthetic Valve Endocarditis: A Case Report
title_full_unstemmed Serum Bactericidal Activity Levels Monitor to Guide Intravenous Dalbavancin Chronic Suppressive Therapy of Inoperable Staphylococcal Prosthetic Valve Endocarditis: A Case Report
title_short Serum Bactericidal Activity Levels Monitor to Guide Intravenous Dalbavancin Chronic Suppressive Therapy of Inoperable Staphylococcal Prosthetic Valve Endocarditis: A Case Report
title_sort serum bactericidal activity levels monitor to guide intravenous dalbavancin chronic suppressive therapy of inoperable staphylococcal prosthetic valve endocarditis: a case report
topic Id Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6847610/
https://www.ncbi.nlm.nih.gov/pubmed/31737736
http://dx.doi.org/10.1093/ofid/ofz427
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