Identification Of Natural Compound Derivative For Inhibition Of XLF And Overcoming Chemoresistance In Colorectal Cancer Cells

PURPOSE: A previous study has identified that XRCC4-like factor (XLF) is a potential target to overcome resistance to 5-fluorouracil (5-Fu) and oxaliplatin (OXA) in colorectal cancer (CRC). The purpose of this study is to develop potent XLF inhibitors to chemoresistance in CRC. METHODS: Virtual scre...

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Detalles Bibliográficos
Autores principales: Liu, Zhuo, Yu, Miao, Fei, Bingyuan, Sun, Jing, Wang, Dongxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6847993/
https://www.ncbi.nlm.nih.gov/pubmed/31806933
http://dx.doi.org/10.2147/DDDT.S215967

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