Real-time hyperpolarized (13)C magnetic resonance detects increased pyruvate oxidation in pyruvate dehydrogenase kinase 2/4–double knockout mouse livers

The pyruvate dehydrogenase complex (PDH) critically regulates carbohydrate metabolism. Phosphorylation of PDH by one of the pyruvate dehydrogenase kinases 1–4 (PDK1–4) decreases the flux of carbohydrates into the TCA cycle. Inhibition of PDKs increases oxidative metabolism of carbohydrates, so targe...

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Detalles Bibliográficos
Autores principales: Sharma, Gaurav, Wu, Cheng-Yang, Wynn, R. Max, Gui, Wenjun, Malloy, Craig R., Sherry, A. Dean, Chuang, David T., Khemtong, Chalermchai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848094/
https://www.ncbi.nlm.nih.gov/pubmed/31712597
http://dx.doi.org/10.1038/s41598-019-52952-6

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