Magneto-Optical Characteristics of Streptavidin-Coated Fe(3)O(4)@Au Core-Shell Nanoparticles for Potential Applications on Biomedical Assays

Recently, gold-coated magnetic nanoparticles have drawn the interest of researchers due to their unique magneto-plasmonic characteristics. Previous research has found that the magneto-optical Faraday effect of gold-coated magnetic nanoparticles can be effectively enhanced because of the surface plas...

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Autores principales: Lin, Chin-Wei, Chen, Jian-Ming, Lin, You-Jun, Chao, Ling-Wei, Wei, Sin-Yi, Wu, Chiu-Hsien, Jeng, Chien-Chung, Wang, Li-Min, Chen, Kuen-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848109/
https://www.ncbi.nlm.nih.gov/pubmed/31712564
http://dx.doi.org/10.1038/s41598-019-52773-7
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author Lin, Chin-Wei
Chen, Jian-Ming
Lin, You-Jun
Chao, Ling-Wei
Wei, Sin-Yi
Wu, Chiu-Hsien
Jeng, Chien-Chung
Wang, Li-Min
Chen, Kuen-Lin
author_facet Lin, Chin-Wei
Chen, Jian-Ming
Lin, You-Jun
Chao, Ling-Wei
Wei, Sin-Yi
Wu, Chiu-Hsien
Jeng, Chien-Chung
Wang, Li-Min
Chen, Kuen-Lin
author_sort Lin, Chin-Wei
collection PubMed
description Recently, gold-coated magnetic nanoparticles have drawn the interest of researchers due to their unique magneto-plasmonic characteristics. Previous research has found that the magneto-optical Faraday effect of gold-coated magnetic nanoparticles can be effectively enhanced because of the surface plasmon resonance of the gold shell. Furthermore, gold-coated magnetic nanoparticles are ideal for biomedical applications because of their high stability and biocompatibility. In this work, we synthesized Fe(3)O(4)@Au core-shell nanoparticles and coated streptavidin (STA) on the surface. Streptavidin is a protein which can selectively bind to biotin with a strong affinity. STA is widely used in biotechnology research including enzyme-linked immunosorbent assay (ELISA), time-resolved immunofluorescence (TRFIA), biosensors, and targeted pharmaceuticals. The Faraday magneto-optical characteristics of the biofunctionalized Fe(3)O(4)@Au nanoparticles were measured and studied. We showed that the streptavidin-coated Fe(3)O(4)@Au nanoparticles still possessed the enhanced magneto-optical Faraday effect. As a result, the possibility of using biofunctionalized Fe(3)O(4)@Au nanoparticles for magneto-optical biomedical assays should be explored.
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spelling pubmed-68481092019-11-19 Magneto-Optical Characteristics of Streptavidin-Coated Fe(3)O(4)@Au Core-Shell Nanoparticles for Potential Applications on Biomedical Assays Lin, Chin-Wei Chen, Jian-Ming Lin, You-Jun Chao, Ling-Wei Wei, Sin-Yi Wu, Chiu-Hsien Jeng, Chien-Chung Wang, Li-Min Chen, Kuen-Lin Sci Rep Article Recently, gold-coated magnetic nanoparticles have drawn the interest of researchers due to their unique magneto-plasmonic characteristics. Previous research has found that the magneto-optical Faraday effect of gold-coated magnetic nanoparticles can be effectively enhanced because of the surface plasmon resonance of the gold shell. Furthermore, gold-coated magnetic nanoparticles are ideal for biomedical applications because of their high stability and biocompatibility. In this work, we synthesized Fe(3)O(4)@Au core-shell nanoparticles and coated streptavidin (STA) on the surface. Streptavidin is a protein which can selectively bind to biotin with a strong affinity. STA is widely used in biotechnology research including enzyme-linked immunosorbent assay (ELISA), time-resolved immunofluorescence (TRFIA), biosensors, and targeted pharmaceuticals. The Faraday magneto-optical characteristics of the biofunctionalized Fe(3)O(4)@Au nanoparticles were measured and studied. We showed that the streptavidin-coated Fe(3)O(4)@Au nanoparticles still possessed the enhanced magneto-optical Faraday effect. As a result, the possibility of using biofunctionalized Fe(3)O(4)@Au nanoparticles for magneto-optical biomedical assays should be explored. Nature Publishing Group UK 2019-11-11 /pmc/articles/PMC6848109/ /pubmed/31712564 http://dx.doi.org/10.1038/s41598-019-52773-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lin, Chin-Wei
Chen, Jian-Ming
Lin, You-Jun
Chao, Ling-Wei
Wei, Sin-Yi
Wu, Chiu-Hsien
Jeng, Chien-Chung
Wang, Li-Min
Chen, Kuen-Lin
Magneto-Optical Characteristics of Streptavidin-Coated Fe(3)O(4)@Au Core-Shell Nanoparticles for Potential Applications on Biomedical Assays
title Magneto-Optical Characteristics of Streptavidin-Coated Fe(3)O(4)@Au Core-Shell Nanoparticles for Potential Applications on Biomedical Assays
title_full Magneto-Optical Characteristics of Streptavidin-Coated Fe(3)O(4)@Au Core-Shell Nanoparticles for Potential Applications on Biomedical Assays
title_fullStr Magneto-Optical Characteristics of Streptavidin-Coated Fe(3)O(4)@Au Core-Shell Nanoparticles for Potential Applications on Biomedical Assays
title_full_unstemmed Magneto-Optical Characteristics of Streptavidin-Coated Fe(3)O(4)@Au Core-Shell Nanoparticles for Potential Applications on Biomedical Assays
title_short Magneto-Optical Characteristics of Streptavidin-Coated Fe(3)O(4)@Au Core-Shell Nanoparticles for Potential Applications on Biomedical Assays
title_sort magneto-optical characteristics of streptavidin-coated fe(3)o(4)@au core-shell nanoparticles for potential applications on biomedical assays
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848109/
https://www.ncbi.nlm.nih.gov/pubmed/31712564
http://dx.doi.org/10.1038/s41598-019-52773-7
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