Cargando…
Proposal for a Quantitative (18)F-FDG PET/CT Metabolic Parameter to Assess the Intensity of Bone Involvement in Multiple Myeloma
Many efforts have been made to standardize the interpretation of (18)F-FDG PET/CT in multiple myeloma (MM) with qualitative visual analysis or with quantitative metabolic parameters using various methods for lesion segmentation of PET images. The aim of this study was to propose a quantitative metho...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848137/ https://www.ncbi.nlm.nih.gov/pubmed/31712729 http://dx.doi.org/10.1038/s41598-019-52740-2 |
_version_ | 1783469030309363712 |
---|---|
author | Takahashi, Maria E. S. Mosci, Camila Souza, Edna M. Brunetto, Sérgio Q. Etchebehere, Elba Santos, Allan O. Camacho, Mariana R. Miranda, Eliana Lima, Mariana C. L. Amorim, Barbara J. de Souza, Carmino Pericole, Fernando V. Lorand-Metze, Irene Ramos, Celso D. |
author_facet | Takahashi, Maria E. S. Mosci, Camila Souza, Edna M. Brunetto, Sérgio Q. Etchebehere, Elba Santos, Allan O. Camacho, Mariana R. Miranda, Eliana Lima, Mariana C. L. Amorim, Barbara J. de Souza, Carmino Pericole, Fernando V. Lorand-Metze, Irene Ramos, Celso D. |
author_sort | Takahashi, Maria E. S. |
collection | PubMed |
description | Many efforts have been made to standardize the interpretation of (18)F-FDG PET/CT in multiple myeloma (MM) with qualitative visual analysis or with quantitative metabolic parameters using various methods for lesion segmentation of PET images. The aim of this study was to propose a quantitative method for bone and bone marrow evaluation of (18)F-FDG PET/CT considering the extent and intensity of bone (18)F-FDG uptake: Intensity of Bone Involvement (IBI). Whole body (18)F-FDG PET/CT of 59 consecutive MM patients were evaluated. Compact bone tissue was segmented in PET images using a global threshold for HU of the registered CT image. A whole skeleton mask was created and the percentage of its volume with (18)F-FDG uptake above hepatic uptake was calculated (Percentage of Bone Involvement - PBI). IBI was defined by multiplying PBI by mean SUV above hepatic uptake. IBI was compared with visual analysis performed by two experienced nuclear medicine physicians. IBI calculation was feasible in all images (range:0.00–1.35). Visual analysis categorized PET exams into three groups (negative/mild, moderate and marked bone involvement), that had different ranges of IBI (multi comparison analysis, p < 0.0001). There was an inverse correlation between the patients’ hemoglobin values and IBI (r = −0.248;p = 0.02). IBI score is an objective measure of bone and bone marrow involvement in MM, allowing the categorization of patients in different degrees of aggressiveness of the bone disease. The next step is to validate IBI in a larger group of patients, before and after treatment and in a multicentre setting. |
format | Online Article Text |
id | pubmed-6848137 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-68481372019-11-19 Proposal for a Quantitative (18)F-FDG PET/CT Metabolic Parameter to Assess the Intensity of Bone Involvement in Multiple Myeloma Takahashi, Maria E. S. Mosci, Camila Souza, Edna M. Brunetto, Sérgio Q. Etchebehere, Elba Santos, Allan O. Camacho, Mariana R. Miranda, Eliana Lima, Mariana C. L. Amorim, Barbara J. de Souza, Carmino Pericole, Fernando V. Lorand-Metze, Irene Ramos, Celso D. Sci Rep Article Many efforts have been made to standardize the interpretation of (18)F-FDG PET/CT in multiple myeloma (MM) with qualitative visual analysis or with quantitative metabolic parameters using various methods for lesion segmentation of PET images. The aim of this study was to propose a quantitative method for bone and bone marrow evaluation of (18)F-FDG PET/CT considering the extent and intensity of bone (18)F-FDG uptake: Intensity of Bone Involvement (IBI). Whole body (18)F-FDG PET/CT of 59 consecutive MM patients were evaluated. Compact bone tissue was segmented in PET images using a global threshold for HU of the registered CT image. A whole skeleton mask was created and the percentage of its volume with (18)F-FDG uptake above hepatic uptake was calculated (Percentage of Bone Involvement - PBI). IBI was defined by multiplying PBI by mean SUV above hepatic uptake. IBI was compared with visual analysis performed by two experienced nuclear medicine physicians. IBI calculation was feasible in all images (range:0.00–1.35). Visual analysis categorized PET exams into three groups (negative/mild, moderate and marked bone involvement), that had different ranges of IBI (multi comparison analysis, p < 0.0001). There was an inverse correlation between the patients’ hemoglobin values and IBI (r = −0.248;p = 0.02). IBI score is an objective measure of bone and bone marrow involvement in MM, allowing the categorization of patients in different degrees of aggressiveness of the bone disease. The next step is to validate IBI in a larger group of patients, before and after treatment and in a multicentre setting. Nature Publishing Group UK 2019-11-11 /pmc/articles/PMC6848137/ /pubmed/31712729 http://dx.doi.org/10.1038/s41598-019-52740-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Takahashi, Maria E. S. Mosci, Camila Souza, Edna M. Brunetto, Sérgio Q. Etchebehere, Elba Santos, Allan O. Camacho, Mariana R. Miranda, Eliana Lima, Mariana C. L. Amorim, Barbara J. de Souza, Carmino Pericole, Fernando V. Lorand-Metze, Irene Ramos, Celso D. Proposal for a Quantitative (18)F-FDG PET/CT Metabolic Parameter to Assess the Intensity of Bone Involvement in Multiple Myeloma |
title | Proposal for a Quantitative (18)F-FDG PET/CT Metabolic Parameter to Assess the Intensity of Bone Involvement in Multiple Myeloma |
title_full | Proposal for a Quantitative (18)F-FDG PET/CT Metabolic Parameter to Assess the Intensity of Bone Involvement in Multiple Myeloma |
title_fullStr | Proposal for a Quantitative (18)F-FDG PET/CT Metabolic Parameter to Assess the Intensity of Bone Involvement in Multiple Myeloma |
title_full_unstemmed | Proposal for a Quantitative (18)F-FDG PET/CT Metabolic Parameter to Assess the Intensity of Bone Involvement in Multiple Myeloma |
title_short | Proposal for a Quantitative (18)F-FDG PET/CT Metabolic Parameter to Assess the Intensity of Bone Involvement in Multiple Myeloma |
title_sort | proposal for a quantitative (18)f-fdg pet/ct metabolic parameter to assess the intensity of bone involvement in multiple myeloma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848137/ https://www.ncbi.nlm.nih.gov/pubmed/31712729 http://dx.doi.org/10.1038/s41598-019-52740-2 |
work_keys_str_mv | AT takahashimariaes proposalforaquantitative18ffdgpetctmetabolicparametertoassesstheintensityofboneinvolvementinmultiplemyeloma AT moscicamila proposalforaquantitative18ffdgpetctmetabolicparametertoassesstheintensityofboneinvolvementinmultiplemyeloma AT souzaednam proposalforaquantitative18ffdgpetctmetabolicparametertoassesstheintensityofboneinvolvementinmultiplemyeloma AT brunettosergioq proposalforaquantitative18ffdgpetctmetabolicparametertoassesstheintensityofboneinvolvementinmultiplemyeloma AT etchebehereelba proposalforaquantitative18ffdgpetctmetabolicparametertoassesstheintensityofboneinvolvementinmultiplemyeloma AT santosallano proposalforaquantitative18ffdgpetctmetabolicparametertoassesstheintensityofboneinvolvementinmultiplemyeloma AT camachomarianar proposalforaquantitative18ffdgpetctmetabolicparametertoassesstheintensityofboneinvolvementinmultiplemyeloma AT mirandaeliana proposalforaquantitative18ffdgpetctmetabolicparametertoassesstheintensityofboneinvolvementinmultiplemyeloma AT limamarianacl proposalforaquantitative18ffdgpetctmetabolicparametertoassesstheintensityofboneinvolvementinmultiplemyeloma AT amorimbarbaraj proposalforaquantitative18ffdgpetctmetabolicparametertoassesstheintensityofboneinvolvementinmultiplemyeloma AT desouzacarmino proposalforaquantitative18ffdgpetctmetabolicparametertoassesstheintensityofboneinvolvementinmultiplemyeloma AT pericolefernandov proposalforaquantitative18ffdgpetctmetabolicparametertoassesstheintensityofboneinvolvementinmultiplemyeloma AT lorandmetzeirene proposalforaquantitative18ffdgpetctmetabolicparametertoassesstheintensityofboneinvolvementinmultiplemyeloma AT ramoscelsod proposalforaquantitative18ffdgpetctmetabolicparametertoassesstheintensityofboneinvolvementinmultiplemyeloma |