Cargando…
Effects of the duration of postresuscitation hyperoxic ventilation on neurological outcome and survival in an asphyxial cardiac arrest rat model
Cardiac arrest leads to sudden cessation of oxygen supply and cerebral hypoxia occurs when there is not sufficient oxygen supplied to the brain. Current Guidelines for adult cardiopulmonary resuscitation (CPR) and emergency cardiovascular care recommend the use of 100% oxygen during resuscitative ef...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848183/ https://www.ncbi.nlm.nih.gov/pubmed/31712629 http://dx.doi.org/10.1038/s41598-019-52477-y |
_version_ | 1783469041173659648 |
---|---|
author | Hu, Tongyi Wang, Jianjie Wang, Shuangwei Li, Jingru Chen, Bihua Zuo, Feng Zhang, Lei Huang, Yuanyuan Li, Yongqin |
author_facet | Hu, Tongyi Wang, Jianjie Wang, Shuangwei Li, Jingru Chen, Bihua Zuo, Feng Zhang, Lei Huang, Yuanyuan Li, Yongqin |
author_sort | Hu, Tongyi |
collection | PubMed |
description | Cardiac arrest leads to sudden cessation of oxygen supply and cerebral hypoxia occurs when there is not sufficient oxygen supplied to the brain. Current Guidelines for adult cardiopulmonary resuscitation (CPR) and emergency cardiovascular care recommend the use of 100% oxygen during resuscitative efforts to maximize the probability of achieving the return of spontaneous circulation (ROSC). However, the optimal strategy for oxygen management after ROSC is still debatable. The aim of the present study was to evaluate the effects of the duration of post-resuscitation hyperoxic ventilation on neurological outcomes in asphyxial cardiac arrest rats treated with targeted temperature management (TTM). Asphyxia was induced by blocking the endotracheal tube in 80 adult male Sprague-Dawley rats. CPR begun after 7 min of untreated cardiac arrest. Animals were randomized to either the normoxic control under normothermia (NNC) group or to one of the 4 experimental groups (n = 16 each) immediately after ROSC: ventilated with 100% oxygen for 0 (O(2)_0h), 1 (O(2)_1h), 3 (O(2)_3h), or 5 (O(2)_5h) h and ventilated with room air thereafter under TTM. Physiological variables were recorded at baseline and during the 6 h postresuscitation monitoring period. Animals were closely observed for 96 h to assess neurologic recovery and survival. There were no significant differences in baseline measurements between groups, and all animals were successfully resuscitated. There were significant interactions between the duration of 100% oxygen administration and hemodynamics as well as, myocardial and cerebral injuries. Among all the durations of hyperoxic ventilation investigated, significantly lower neurological deficit scores and higher survival rates were observed in the O(2)_3h group than in the NNC group. In conclusion, postresuscitation hyperoxic ventilation leads to improved PaO(2), PaCO(2), hemodynamic, myocardial and cerebral recovery in asphyxial cardiac arrest rats treated with TTM. However, the beneficial effects of high concentration-oxygen are duration dependent and ventilation with 100% oxygen during induced hypothermia contributes to improved neurological recovery and survival after 96 h. |
format | Online Article Text |
id | pubmed-6848183 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-68481832019-11-19 Effects of the duration of postresuscitation hyperoxic ventilation on neurological outcome and survival in an asphyxial cardiac arrest rat model Hu, Tongyi Wang, Jianjie Wang, Shuangwei Li, Jingru Chen, Bihua Zuo, Feng Zhang, Lei Huang, Yuanyuan Li, Yongqin Sci Rep Article Cardiac arrest leads to sudden cessation of oxygen supply and cerebral hypoxia occurs when there is not sufficient oxygen supplied to the brain. Current Guidelines for adult cardiopulmonary resuscitation (CPR) and emergency cardiovascular care recommend the use of 100% oxygen during resuscitative efforts to maximize the probability of achieving the return of spontaneous circulation (ROSC). However, the optimal strategy for oxygen management after ROSC is still debatable. The aim of the present study was to evaluate the effects of the duration of post-resuscitation hyperoxic ventilation on neurological outcomes in asphyxial cardiac arrest rats treated with targeted temperature management (TTM). Asphyxia was induced by blocking the endotracheal tube in 80 adult male Sprague-Dawley rats. CPR begun after 7 min of untreated cardiac arrest. Animals were randomized to either the normoxic control under normothermia (NNC) group or to one of the 4 experimental groups (n = 16 each) immediately after ROSC: ventilated with 100% oxygen for 0 (O(2)_0h), 1 (O(2)_1h), 3 (O(2)_3h), or 5 (O(2)_5h) h and ventilated with room air thereafter under TTM. Physiological variables were recorded at baseline and during the 6 h postresuscitation monitoring period. Animals were closely observed for 96 h to assess neurologic recovery and survival. There were no significant differences in baseline measurements between groups, and all animals were successfully resuscitated. There were significant interactions between the duration of 100% oxygen administration and hemodynamics as well as, myocardial and cerebral injuries. Among all the durations of hyperoxic ventilation investigated, significantly lower neurological deficit scores and higher survival rates were observed in the O(2)_3h group than in the NNC group. In conclusion, postresuscitation hyperoxic ventilation leads to improved PaO(2), PaCO(2), hemodynamic, myocardial and cerebral recovery in asphyxial cardiac arrest rats treated with TTM. However, the beneficial effects of high concentration-oxygen are duration dependent and ventilation with 100% oxygen during induced hypothermia contributes to improved neurological recovery and survival after 96 h. Nature Publishing Group UK 2019-11-11 /pmc/articles/PMC6848183/ /pubmed/31712629 http://dx.doi.org/10.1038/s41598-019-52477-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Hu, Tongyi Wang, Jianjie Wang, Shuangwei Li, Jingru Chen, Bihua Zuo, Feng Zhang, Lei Huang, Yuanyuan Li, Yongqin Effects of the duration of postresuscitation hyperoxic ventilation on neurological outcome and survival in an asphyxial cardiac arrest rat model |
title | Effects of the duration of postresuscitation hyperoxic ventilation on neurological outcome and survival in an asphyxial cardiac arrest rat model |
title_full | Effects of the duration of postresuscitation hyperoxic ventilation on neurological outcome and survival in an asphyxial cardiac arrest rat model |
title_fullStr | Effects of the duration of postresuscitation hyperoxic ventilation on neurological outcome and survival in an asphyxial cardiac arrest rat model |
title_full_unstemmed | Effects of the duration of postresuscitation hyperoxic ventilation on neurological outcome and survival in an asphyxial cardiac arrest rat model |
title_short | Effects of the duration of postresuscitation hyperoxic ventilation on neurological outcome and survival in an asphyxial cardiac arrest rat model |
title_sort | effects of the duration of postresuscitation hyperoxic ventilation on neurological outcome and survival in an asphyxial cardiac arrest rat model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848183/ https://www.ncbi.nlm.nih.gov/pubmed/31712629 http://dx.doi.org/10.1038/s41598-019-52477-y |
work_keys_str_mv | AT hutongyi effectsofthedurationofpostresuscitationhyperoxicventilationonneurologicaloutcomeandsurvivalinanasphyxialcardiacarrestratmodel AT wangjianjie effectsofthedurationofpostresuscitationhyperoxicventilationonneurologicaloutcomeandsurvivalinanasphyxialcardiacarrestratmodel AT wangshuangwei effectsofthedurationofpostresuscitationhyperoxicventilationonneurologicaloutcomeandsurvivalinanasphyxialcardiacarrestratmodel AT lijingru effectsofthedurationofpostresuscitationhyperoxicventilationonneurologicaloutcomeandsurvivalinanasphyxialcardiacarrestratmodel AT chenbihua effectsofthedurationofpostresuscitationhyperoxicventilationonneurologicaloutcomeandsurvivalinanasphyxialcardiacarrestratmodel AT zuofeng effectsofthedurationofpostresuscitationhyperoxicventilationonneurologicaloutcomeandsurvivalinanasphyxialcardiacarrestratmodel AT zhanglei effectsofthedurationofpostresuscitationhyperoxicventilationonneurologicaloutcomeandsurvivalinanasphyxialcardiacarrestratmodel AT huangyuanyuan effectsofthedurationofpostresuscitationhyperoxicventilationonneurologicaloutcomeandsurvivalinanasphyxialcardiacarrestratmodel AT liyongqin effectsofthedurationofpostresuscitationhyperoxicventilationonneurologicaloutcomeandsurvivalinanasphyxialcardiacarrestratmodel |